8-(2-噻唑)-1,4-二噁螺[4.5]-8-癸醇合成路线 （共 3 条）
反应条件
1: 1,3-thiazole With n-butyllithium in tetrahydrofuran; hexanes
T=-78°C; 1 h;
2: 1,4-cyclohexanedione monoacetal in tetrahydrofuran; hexanes
T=-78°C; 3 h;
3: With water in tetrahydrofuran; hexanes
T=-78 - 20°C;
参考文献
PFIZER LIMITED; BURGESS, Gary
Patent: WO2012/114223 A1, 2012 ;
Location in patent: Page/Page column 46 ;
WO 2012/114223 A1
反应条件
1: 1,3-thiazole With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: 1,4-cyclohexanedione monoacetal in tetrahydrofuran; hexane
T=-78°C; 3 h;
3: With water in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Xue, Chu-Biao; Metcalf, Brian W.; Han, Amy Qi; Robinson, Darius J.; Zheng, Changsheng; Wang, Anlai; Zhang, Yingxin
Patent: US2005/192302 A1, 2005 ;
Location in patent: Page/Page column 26 ;
US 20050192302 A1
反应条件
1: 2-bromo-1,3-thiazole With n-butyllithium in diethyl ether; hexane
T=-78 - -60°C; 0.25 - 0.916667 h;
2: 1,4-cyclohexanedione monoacetal in diethyl ether; hexane
T=-78 - 20°C; 3 h; Product distribution / selectivity;
参考文献
ABBOTT LABORATORIES
Patent: US2009/124671 A1, 2009 ;
Location in patent: Page/Page column 21; 23 ;
