1-(O-甲苯基)己烷-2,5-二酮合成路线 （共 17 条）
反应条件
1: 4-methylbenzyl chloride With chloro-trimethyl-silane; zinc in tetrahydrofuran
T=40°C; 4 h;
2: carbon monoxide; methyl vinyl ketone With tetrakis(triphenylphosphine) palladium(0); chloro-trimethyl-silane; lithium chloride in tetrahydrofuran
T=30°C; P=760 Torr; 0.583333 h;
参考文献
Yuguchi, Motoki; Tokuda, Masao; Orito, Kazuhiko
Journal of Organic Chemistry, 2004 , vol. 69, # 3 p. 908 - 914
反应条件
sulfuric acid; acetic acid in water
T=120°C; 2 h;
参考文献
Kametani, Tetsuji; Tsubuki, Masayoshi; Nemoto, Hideo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 759 - 761
反应条件
oxygen; copper(l) chloride; palladium dichloride in water; N,N-dimethyl-formamide
20 h; Ambient temperature;
参考文献
Kametani, Tetsuji; Kawamura, Kuniaki; Tsubuki, Masayoshi; Honda, Toshio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 1305 - 1310
反应条件
titanium tetrachloride in methanol; dichloromethane; acetone
Ambient temperature;
参考文献
Motoyoshiya; Hongo; Tanaka; Hayashi
Synthetic Communications, 1991 , vol. 21, # 8-9 p. 997 - 1000
反应条件
1: 87 percent / tetrahydrofuran / 1 h / Ambient temperature
2: 86.7 percent / pyridinium chlorochromate / CH2Cl2 / 1.5 h / Ambient temperature
3: 55 percent / oxygen / palladium chloride, cuprous chloride / dimethylformamide; H2O / 20 h / Ambient temperature
View Scheme
参考文献
Kametani, Tetsuji; Kawamura, Kuniaki; Tsubuki, Masayoshi; Honda, Toshio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 1305 - 1310
反应条件
1: 86.7 percent / pyridinium chlorochromate / CH2Cl2 / 1.5 h / Ambient temperature
2: 55 percent / oxygen / palladium chloride, cuprous chloride / dimethylformamide; H2O / 20 h / Ambient temperature
View Scheme
参考文献
Kametani, Tetsuji; Kawamura, Kuniaki; Tsubuki, Masayoshi; Honda, Toshio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 1305 - 1310
反应条件
in tetrahydrofuran
T=-78°C; 1.08333 h;
参考文献
Kitahara, Haruo; Tozawa, Yasuyuki; Fujita, Seikou; Tajiri, Akio; Morita, Noboru; Asao, Toyonobu
Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 9 p. 3362 - 3364
反应条件
1: 90 percent / NaBH4, silica gel / CHCl3; propan-2-ol / 0.25 h
2: 78 percent / alumina / 7 h / Ambient temperature
3: 1.) lithium methylate, 2.) sodium tetraborate, KMnO4 / 1.) methanol, 0-2 deg C, 15 min, 2.) water, room temperature, 30 min
View Scheme
参考文献
Ballini, Roberto; Petrini, Marino; Marotta, Emanuela
Synthetic Communications, 1987 , vol. 17, # 5 p. 543 - 548
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 2 h, 2.) THF, hexane, -70 deg C, 2 h
2: 64 percent / TiCl4 / methanol; acetone; CH2Cl2 / Ambient temperature
View Scheme
参考文献
Motoyoshiya; Hongo; Tanaka; Hayashi
Synthetic Communications, 1991 , vol. 21, # 8-9 p. 997 - 1000
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 2 h, 2.) THF, hexane, -70 deg C, 2 h
2: 64 percent / TiCl4 / methanol; acetone; CH2Cl2 / Ambient temperature
View Scheme
参考文献
Motoyoshiya; Hongo; Tanaka; Hayashi
Synthetic Communications, 1991 , vol. 21, # 8-9 p. 997 - 1000
