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63148-62-9
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471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
70858-10-5
合成路线
（共 8 条）
104157-13-3
→
反应条件
70858-10-5
反应条件
potassium hydroxide 5 h; Heating;
参考文献
Ho, Winston; Tutwiler, Gene F.; Cottrell, Sandra C.; Morgans, Dave J.; Tarhan, Okan; Mohrbacher, Richard J.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2184 - 2190
112-71-0
溴代十四烷
→
反应条件
70858-10-5
反应条件
1: 1.) NaOMe / 1.) reflux, 5 min, 2.) reflux, 2 h 2: 0.73 g / 1 N Ba(OH)2 / methanol / 3 h / 25 °C 3: 79 percent / Et2NH / H2O / 0.5 h / Heating 4: diethyl ether / 16 h / Ambient temperature 5: 3 h / 150 - 160 °C 6: 44 percent / 5percent methanolic KOH / 5 h / Heating View Scheme
参考文献
Ho, Winston; Tutwiler, Gene F.; Cottrell, Sandra C.; Morgans, Dave J.; Tarhan, Okan; Mohrbacher, Richard J.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2184 - 2190
6818-50-4
→
反应条件
70858-10-5
反应条件
1: 99 percent / BF3*MeOH / 6 h / Heating 2: diethyl ether / 16 h / Ambient temperature 3: 3 h / 150 - 160 °C 4: 44 percent / 5percent methanolic KOH / 5 h / Heating View Scheme
参考文献
Ho, Winston; Tutwiler, Gene F.; Cottrell, Sandra C.; Morgans, Dave J.; Tarhan, Okan; Mohrbacher, Richard J.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2184 - 2190
41240-57-7
→
反应条件
70858-10-5
反应条件
1: 0.73 g / 1 N Ba(OH)2 / methanol / 3 h / 25 °C 2: 79 percent / Et2NH / H2O / 0.5 h / Heating 3: diethyl ether / 16 h / Ambient temperature 4: 3 h / 150 - 160 °C 5: 44 percent / 5percent methanolic KOH / 5 h / Heating View Scheme
参考文献
Ho, Winston; Tutwiler, Gene F.; Cottrell, Sandra C.; Morgans, Dave J.; Tarhan, Okan; Mohrbacher, Richard J.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2184 - 2190
73472-08-9
→
反应条件
70858-10-5
反应条件
1: diethyl ether / 16 h / Ambient temperature 2: 3 h / 150 - 160 °C 3: 44 percent / 5percent methanolic KOH / 5 h / Heating View Scheme
参考文献
Ho, Winston; Tutwiler, Gene F.; Cottrell, Sandra C.; Morgans, Dave J.; Tarhan, Okan; Mohrbacher, Richard J.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2184 - 2190
104157-07-5
→
反应条件
70858-10-5
反应条件
1: 79 percent / Et2NH / H2O / 0.5 h / Heating 2: diethyl ether / 16 h / Ambient temperature 3: 3 h / 150 - 160 °C 4: 44 percent / 5percent methanolic KOH / 5 h / Heating View Scheme
参考文献
Ho, Winston; Tutwiler, Gene F.; Cottrell, Sandra C.; Morgans, Dave J.; Tarhan, Okan; Mohrbacher, Richard J.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2184 - 2190
104156-91-4
→
反应条件
70858-10-5
反应条件
1: 3 h / 150 - 160 °C 2: 44 percent / 5percent methanolic KOH / 5 h / Heating View Scheme
参考文献
Ho, Winston; Tutwiler, Gene F.; Cottrell, Sandra C.; Morgans, Dave J.; Tarhan, Okan; Mohrbacher, Richard J.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2184 - 2190
112-71-0
溴代十四烷
+
1759-53-1
环丙甲酸
→
反应条件
70858-10-5
反应条件
n-butyllithium; sodium hydride; diisopropylamine Multistep reaction;
参考文献
Roth; Blankley; Hoefle; Holmes; Roark; Trivedi; Essenburg; Kieft; Krause; Stanfield
Journal of Medicinal Chemistry, 1992 , vol. 35, # 9 p. 1609 - 1617
