2-((3-氯乙基)-3-亚硝基脲基)吡喃葡萄糖合成路线 （共 9 条）
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=0°C; 0.5 h;
参考文献
Montero; Leydet; Messiez-Munoz; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 6 p. 512 - 518
反应条件
pyridine
T=0°C; 12 h;
参考文献
Martinez, Jean; Oiry, Joel; Imbach, Jean Louis; Winternitz, Francois
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 178 - 182
反应条件
pyridine
T=0°C; 12 h;
参考文献
Martinez, Jean; Oiry, Joel; Imbach, Jean Louis; Winternitz, Francois
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 178 - 182
反应条件
pyridine
T=0°C; 12 h;
参考文献
Martinez, Jean; Oiry, Joel; Imbach, Jean Louis; Winternitz, Francois
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 178 - 182
反应条件
pyridine
T=0°C; 1 h;
参考文献
Martinez, Jean; Oiry, Joel; Imbach, Jean Louis; Winternitz, Francois
Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 178 - 182
反应条件
hydrogenchloride; sodium nitrite in ethanol; water
1.) 0 deg C, 30 min, 2.) 25 deg C, 1 h;
参考文献
Sosnovsky; Rao
Journal of Pharmaceutical Sciences, 1991 , vol. 80, # 7 p. 693 - 699
反应条件
pyridine; benzotriazol-1-ol
1.) -10 deg C, 1 h; 2.) 0 deg C, 24 h;
参考文献
Martinez; Oiry; Imbach; Winternitz
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 3 p. 211 - 213
反应条件
1: diethyl ether / Ambient temperature
2: NaNO2, HCO2H / 0.5 h / 0 - 5 °C
View Scheme
参考文献
Lown; Chauhan
Journal of Organic Chemistry, 1981 , vol. 46, # 26 p. 5309 - 5321
反应条件
1: 75 percent / 1M aq. NaOH / diethyl ether; CHCl3 / 3 h / 0 °C
2: 47 percent / NaNO2, HCl / ethanol; H2O / 1.) 0 deg C, 30 min, 2.) 25 deg C, 1 h
View Scheme
参考文献
Sosnovsky; Rao
Journal of Pharmaceutical Sciences, 1991 , vol. 80, # 7 p. 693 - 699
