2-氯-1,10-邻二氮杂菲合成路线 （共 16 条）
反应条件
1: With phosphorus pentachloride; trichlorophosphate Inert atmosphereCooling in iceReflux; 2: With ammonia in water Alkaline conditions;
参考文献
B.R.A.H.M.S GmbH; HOSHINO, Mikio; YANO, Toshisada; YAMANAKA, Yasukazu
Patent: WO2012/124310 A1, 2012 ;
Location in patent: Page/Page column 33-34 ;
反应条件
sodium chloride; trichlorophosphate in N,N-dimethyl-formamide T=100°C; 6 h;
参考文献
Engel, Yoni; Dahan, Adi; Rozenshine-Kemelmakher, Emily; Gozin, Michael
Journal of Organic Chemistry, 2007 , vol. 72, # 7 p. 2318 - 2328
反应条件
1: 71 percent / AcOH; aq. H2O2 / 16 h 2: 52 percent / NaCl; POCl3 / dimethylformamide / 6 h / 100 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 72, # 7 p. 2318 - 2328
反应条件
1.1: potassium hexacyanoferrate(III); sodium hydroxide / water / 10 - 20 °C 2.1: phosphorus pentachloride; trichlorophosphate / Inert atmosphere; Cooling in ice; Reflux 2.2: Alkaline conditions View Scheme
反应条件
Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), , p. 736 - 742
反应条件
sodium methylate 19 h; Heating;
参考文献
Krapcho, A. Paul; Sparapani, Silvia
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 4 p. 1167 - 1170
反应条件
in methanol Heating;
参考文献
Pijper; Van der Goot; Timmerman; Nauta Th.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 5 p. 399 - 404
反应条件
methanol; sodium methylate
参考文献
Karrer; Pletscher
Helvetica Chimica Acta, 1948 , vol. 31, p. 786,793
反应条件
bromine in nitrobenzene
参考文献
Toyota, Shinji; Woods, Craig R.; Benaglia, Maurizio; Siegel, Jay S.
Tetrahedron Letters, 1998 , vol. 39, # 18 p. 2697 - 2700
反应条件
ammonia in various solvent(s) T=160°C;
参考文献
Pijper; Van der Goot; Timmerman; Nauta Th.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 5 p. 399 - 404
