苄基N-[(1S)-2-氨基-1-(羟基甲基)-2-氧代-乙基]氨基甲酸酯合成路线 （共 9 条）
反应条件
1: 1.) DMSO; 2.) triethylamine / 1.) DMF, -5 deg C, 5 min; 2.) DMF, -5 deg C -> room temp., 1 h 2: methanol / Ambient temperature View Scheme
参考文献
Nakazawa, Takashi; Suzuki, Tomiko; Ishii, Masako
Tetrahedron Letters, 1997 , vol. 38, # 52 p. 8951 - 8954
反应条件
ammonia in acetonitrile
T=0°C; 0.25 h;
参考文献
Arnold; Kalantar; Vederas
Journal of the American Chemical Society, 1985 , vol. 107, # 24 p. 7105 - 7109
反应条件
ammonia in methanol
T=0°C;
参考文献
Ranganathan; Vaish; Shah
Journal of the American Chemical Society, 1994 , vol. 116, # 15 p. 6545 - 6557
参考文献
FARMITALIA CARLO ERBA S.r.l.
Patent: EP175323 B1, 1992 ;
反应条件
hexamethylphosphorous triamide dichloride; ammonia in dichloromethane
1) 30 min, -20 deg C, 2) 4 h, r.t.;
参考文献
Appel, Rolf; Hiester, Ernst
Chemische Berichte, 1983 , vol. 116, # 5 p. 2037 - 2040
参考文献
Pfizer Inc.
Patent: US4454328 A1, 1984 ;
反应条件
potassium hydrogencarbonate; ethyl acetate
Behandeln des erhaltenen N-Benzyloxycarbonyl-L-serin-methylesters mit methanol. NH3;
参考文献
Fruton
Journal of Biological Chemistry, 1942 , vol. 146, p. 463,469
反应条件
hydrogen; palladium
1.) MeOH, room temp., 3 h, 2.) DMF, THF, room temp., 15 h; Yield given. Multistep reaction;
参考文献
Kitada; Ashida; Maki; Fujino; Hirai; Yasuhara; Nakajima; Takeyama; Koyama; Yajima
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 3 p. 887 - 892
反应条件
palladium
Hydrogenation;
参考文献
Hanson,R.W.; Rydon,H.N.
Journal of the Chemical Society, 1964 , p. 836 - 842
