2-(3-羟基-1-金刚烷)-2-氧代乙酸合成路线 （共 8 条）
反应条件
1: With sodium hydroxide in tetrahydrofuran; water T=20°C; pH=13.24; 16 h; 2: With hydrogenchloride; sodium hydrogencarbonate in tetrahydrofuran; water T=4 - 20°C; pH=1.4 - 1.77; 101.76 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2004/52850 A2, 2004 ;
Location in patent: Page 66 ;
WO 2004/052850 A2
反应条件
potassium permanganate; potassium hydroxide in water T=90°C;
参考文献
Pan, Xianhua; Lu, Qingling; Li, Xiaojun; Zhang, Jianshui; Yu, Wansheng; Liu, Feng
Journal of Chemical Research, 2013 , vol. 37, # 12 p. 722 - 723
反应条件
1: With sodium hydroxide; NaMnO4; water in tert-butyl alcohol T=30 - 40°C; 3.5 h; 2: With hydrogenchloride; water in isopropyl alcohol; tert-butyl alcohol Product distribution / selectivity;
参考文献
Williams, Eric L.
Patent: US2006/63950 A1, 2006 ;
Location in patent: Page/Page column 4 ;
反应条件
potassium permanganate; potassium hydroxide in water T=50 - 80°C; 12 h;
参考文献
Journal of Chemical Research, , vol. 37, # 12 p. 722 - 723
反应条件
1: With sodium hydroxide; potassium permanganate in water T=20 - 60°C; 11 h; 2: Acidic aqueous solution;
参考文献
US2006/270870 A1, ;
Page/Page column 4 ;
反应条件
1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 25 °C 1.2: 2 h / 25 °C 2.1: tetrahydrofuran / 10 - 20 °C / |Inert atmosphere 3.1: potassium permanganate; potassium hydroxide / water / 90 °C View Scheme
参考文献
Journal of Chemical Research, , vol. 37, # 12 p. 722 - 723
反应条件
1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 25 °C 1.2: 2 h / 25 °C 2.1: tetrahydrofuran / 10 - 20 °C / |Inert atmosphere 3.1: potassium permanganate; potassium hydroxide / water / 12 h / 50 - 80 °C View Scheme
参考文献
Journal of Chemical Research, , vol. 37, # 12 p. 722 - 723
反应条件
1: tetrahydrofuran / 10 - 20 °C / |Inert atmosphere 2: potassium permanganate; potassium hydroxide / water / 12 h / 50 - 80 °C View Scheme
参考文献
Journal of Chemical Research, , vol. 37, # 12 p. 722 - 723
