(2S)-2-(氨基羰基)-2,3-二氢-1H-吡咯-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
1: diiodomethane With diethylzinc in ethylene glycol dimethyl ether; dichloromethane; toluene T=-30 - -25°C; Simmons-Smith Reaction; 0.75 h; 2: BMS-562419 in ethylene glycol dimethyl ether; dichloromethane; toluene T=22 - 24°C; 3: With sodium hydrogencarbonate in ethylene glycol dimethyl ether; dichloromethane; water; toluene T=15°C; 1 h;
参考文献
Sharma, Padam N.; Galvin, Gabriel M.; Boettger, Susan D.; Racha, Saibaba; Zhu, Jingyang; Melton, Jack; Mudryk, Boguslaw M.
Patent: US2006/35954 A1, 2006 ;
Location in patent: Page/Page column 6-7 ;
反应条件
1: diethylzinc / ethylene glycol dimethyl ether; dichloromethane / -30 - 20 °C 2: isopropyl alcohol / 60 °C 3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / ethyl acetate; acetonitrile / 3 h View Scheme
参考文献
Dong, Jizhe; Gong, Yanchun; Liu, Jun; Chen, Xiangfeng; Wen, Xiaoan; Sun, Hongbin
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 4 p. 1383 - 1393
反应条件
1.1: diethylzinc / ethylene glycol dimethyl ether; dichloromethane / -30 - 20 °C
2.1: isopropyl alcohol / 60 °C
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / ethyl acetate; acetonitrile / 3 h
4.1: trifluoroacetic anhydride; pyridine / tetrahydrofuran / 0.5 h / 0 °C
4.2: 18 h / 20 °C
View Scheme
参考文献
Dong, Jizhe; Gong, Yanchun; Liu, Jun; Chen, Xiangfeng; Wen, Xiaoan; Sun, Hongbin
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 4 p. 1383 - 1393
反应条件
1: diethylzinc / ethylene glycol dimethyl ether; dichloromethane / -30 - 20 °C
2: isopropyl alcohol / 60 °C
View Scheme
参考文献
Dong, Jizhe; Gong, Yanchun; Liu, Jun; Chen, Xiangfeng; Wen, Xiaoan; Sun, Hongbin
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 4 p. 1383 - 1393
