N-[(1S)-2-[(1S,3S,5S)-3-氰基-2-氮杂双环[3.1.0]己烷-2-基]-1-(3-羟基三环[3.3.1.13,7]癸烷-1-基)-2-氧代乙基]氨基甲酸 1,1-二甲基乙酯合成路线

709031-43-6N-[(1S)-2-[(1S,3S,5S)-3-氰基-2-氮杂双环[3.1.0]己烷-2-基]-1-(3-羟基三环[3.3.1.13,7]癸烷-1-基)-2-氧代乙基]氨基甲酸 1,1-二甲基乙酯

参考文献

Augeri, David J.; Robl, Jeffrey A.; Betebenner, David A.; Magnin, David R.; Khanna, Ashish; Robertson, James G.; Wang, Aiying; Simpkins, Ligaya M.; Taunk, Prakash; Huang, Qi; Han, Song-Ping; Abboa-Offei, Benoni; Cap, Michael; Xin, Li; Tao, Li; Tozzo, Effie; Welzel, Gustav E.; Egan, Donald M.; Marcinkeviciene, Jovita; Chang, Shu Y.; Biller, Scott A.; Kirby, Mark S.; Parker, Rex A.; Hamann, Lawrence G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 15 p. 5025 - 5037

361441-95-4(alphaS)-alpha-[[(1R)-2-羟基-1-苯基乙基]氨基]-金刚烷-1-乙腈

709031-43-6N-[(1S)-2-[(1S,3S,5S)-3-氰基-2-氮杂双环[3.1.0]己烷-2-基]-1-(3-羟基三环[3.3.1.13,7]癸烷-1-基)-2-氧代乙基]氨基甲酸 1,1-二甲基乙酯

参考文献

Augeri, David J.; Robl, Jeffrey A.; Betebenner, David A.; Magnin, David R.; Khanna, Ashish; Robertson, James G.; Wang, Aiying; Simpkins, Ligaya M.; Taunk, Prakash; Huang, Qi; Han, Song-Ping; Abboa-Offei, Benoni; Cap, Michael; Xin, Li; Tao, Li; Tozzo, Effie; Welzel, Gustav E.; Egan, Donald M.; Marcinkeviciene, Jovita; Chang, Shu Y.; Biller, Scott A.; Kirby, Mark S.; Parker, Rex A.; Hamann, Lawrence G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 15 p. 5025 - 5037

2094-74-81-金刚烷甲醛

709031-43-6N-[(1S)-2-[(1S,3S,5S)-3-氰基-2-氮杂双环[3.1.0]己烷-2-基]-1-(3-羟基三环[3.3.1.13,7]癸烷-1-基)-2-氧代乙基]氨基甲酸 1,1-二甲基乙酯

参考文献

Augeri, David J.; Robl, Jeffrey A.; Betebenner, David A.; Magnin, David R.; Khanna, Ashish; Robertson, James G.; Wang, Aiying; Simpkins, Ligaya M.; Taunk, Prakash; Huang, Qi; Han, Song-Ping; Abboa-Offei, Benoni; Cap, Michael; Xin, Li; Tao, Li; Tozzo, Effie; Welzel, Gustav E.; Egan, Donald M.; Marcinkeviciene, Jovita; Chang, Shu Y.; Biller, Scott A.; Kirby, Mark S.; Parker, Rex A.; Hamann, Lawrence G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 15 p. 5025 - 5037

770-71-81-金刚烷甲醇

709031-43-6N-[(1S)-2-[(1S,3S,5S)-3-氰基-2-氮杂双环[3.1.0]己烷-2-基]-1-(3-羟基三环[3.3.1.13,7]癸烷-1-基)-2-氧代乙基]氨基甲酸 1,1-二甲基乙酯

参考文献

Augeri, David J.; Robl, Jeffrey A.; Betebenner, David A.; Magnin, David R.; Khanna, Ashish; Robertson, James G.; Wang, Aiying; Simpkins, Ligaya M.; Taunk, Prakash; Huang, Qi; Han, Song-Ping; Abboa-Offei, Benoni; Cap, Michael; Xin, Li; Tao, Li; Tozzo, Effie; Welzel, Gustav E.; Egan, Donald M.; Marcinkeviciene, Jovita; Chang, Shu Y.; Biller, Scott A.; Kirby, Mark S.; Parker, Rex A.; Hamann, Lawrence G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 15 p. 5025 - 5037

828-51-31-金刚烷甲酸

709031-43-6N-[(1S)-2-[(1S,3S,5S)-3-氰基-2-氮杂双环[3.1.0]己烷-2-基]-1-(3-羟基三环[3.3.1.13,7]癸烷-1-基)-2-氧代乙基]氨基甲酸 1,1-二甲基乙酯

参考文献

Augeri, David J.; Robl, Jeffrey A.; Betebenner, David A.; Magnin, David R.; Khanna, Ashish; Robertson, James G.; Wang, Aiying; Simpkins, Ligaya M.; Taunk, Prakash; Huang, Qi; Han, Song-Ping; Abboa-Offei, Benoni; Cap, Michael; Xin, Li; Tao, Li; Tozzo, Effie; Welzel, Gustav E.; Egan, Donald M.; Marcinkeviciene, Jovita; Chang, Shu Y.; Biller, Scott A.; Kirby, Mark S.; Parker, Rex A.; Hamann, Lawrence G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 15 p. 5025 - 5037

711-01-31-金刚烷甲酸甲酯

709031-43-6N-[(1S)-2-[(1S,3S,5S)-3-氰基-2-氮杂双环[3.1.0]己烷-2-基]-1-(3-羟基三环[3.3.1.13,7]癸烷-1-基)-2-氧代乙基]氨基甲酸 1,1-二甲基乙酯

参考文献

Augeri, David J.; Robl, Jeffrey A.; Betebenner, David A.; Magnin, David R.; Khanna, Ashish; Robertson, James G.; Wang, Aiying; Simpkins, Ligaya M.; Taunk, Prakash; Huang, Qi; Han, Song-Ping; Abboa-Offei, Benoni; Cap, Michael; Xin, Li; Tao, Li; Tozzo, Effie; Welzel, Gustav E.; Egan, Donald M.; Marcinkeviciene, Jovita; Chang, Shu Y.; Biller, Scott A.; Kirby, Mark S.; Parker, Rex A.; Hamann, Lawrence G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 15 p. 5025 - 5037

361442-00-4N-叔丁氧羰基-3-羟基-1-金刚烷基-D-甘氨酸

709031-43-6N-[(1S)-2-[(1S,3S,5S)-3-氰基-2-氮杂双环[3.1.0]己烷-2-基]-1-(3-羟基三环[3.3.1.13,7]癸烷-1-基)-2-氧代乙基]氨基甲酸 1,1-二甲基乙酯

参考文献

Augeri, David J.; Robl, Jeffrey A.; Betebenner, David A.; Magnin, David R.; Khanna, Ashish; Robertson, James G.; Wang, Aiying; Simpkins, Ligaya M.; Taunk, Prakash; Huang, Qi; Han, Song-Ping; Abboa-Offei, Benoni; Cap, Michael; Xin, Li; Tao, Li; Tozzo, Effie; Welzel, Gustav E.; Egan, Donald M.; Marcinkeviciene, Jovita; Chang, Shu Y.; Biller, Scott A.; Kirby, Mark S.; Parker, Rex A.; Hamann, Lawrence G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 15 p. 5025 - 5037

361441-97-6N-叔丁氧羰基-L-金刚烷基甘氨酸

709031-43-6N-[(1S)-2-[(1S,3S,5S)-3-氰基-2-氮杂双环[3.1.0]己烷-2-基]-1-(3-羟基三环[3.3.1.13,7]癸烷-1-基)-2-氧代乙基]氨基甲酸 1,1-二甲基乙酯

参考文献

Augeri, David J.; Robl, Jeffrey A.; Betebenner, David A.; Magnin, David R.; Khanna, Ashish; Robertson, James G.; Wang, Aiying; Simpkins, Ligaya M.; Taunk, Prakash; Huang, Qi; Han, Song-Ping; Abboa-Offei, Benoni; Cap, Michael; Xin, Li; Tao, Li; Tozzo, Effie; Welzel, Gustav E.; Egan, Donald M.; Marcinkeviciene, Jovita; Chang, Shu Y.; Biller, Scott A.; Kirby, Mark S.; Parker, Rex A.; Hamann, Lawrence G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 15 p. 5025 - 5037

95853-35-3

709031-43-6N-[(1S)-2-[(1S,3S,5S)-3-氰基-2-氮杂双环[3.1.0]己烷-2-基]-1-(3-羟基三环[3.3.1.13,7]癸烷-1-基)-2-氧代乙基]氨基甲酸 1,1-二甲基乙酯

参考文献

Augeri, David J.; Robl, Jeffrey A.; Betebenner, David A.; Magnin, David R.; Khanna, Ashish; Robertson, James G.; Wang, Aiying; Simpkins, Ligaya M.; Taunk, Prakash; Huang, Qi; Han, Song-Ping; Abboa-Offei, Benoni; Cap, Michael; Xin, Li; Tao, Li; Tozzo, Effie; Welzel, Gustav E.; Egan, Donald M.; Marcinkeviciene, Jovita; Chang, Shu Y.; Biller, Scott A.; Kirby, Mark S.; Parker, Rex A.; Hamann, Lawrence G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 15 p. 5025 - 5037

1334321-39-9沙格列汀杂质

709031-43-6N-[(1S)-2-[(1S,3S,5S)-3-氰基-2-氮杂双环[3.1.0]己烷-2-基]-1-(3-羟基三环[3.3.1.13,7]癸烷-1-基)-2-氧代乙基]氨基甲酸 1,1-二甲基乙酯

参考文献

SANDOZ AG; WILHELM, Thorsten
Patent: WO2011/117393 A1, 2011 ;