1.1: triethylamine / methanol 2.1: potassium permanganate; potassium hydroxide / 90 °C 3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / ethyl acetate; acetonitrile / 3 h 4.1: trifluoroacetic anhydride; pyridine / tetrahydrofuran / 0.5 h / 0 °C 4.2: 18 h / 20 °C View Scheme

1.1: 4-(N,N-dimethlyamino)pyridine; trifluoroacetic anhydride; N-ethyl-N,N-diisopropylamine 2.1: water; lithium hydroxide hydrate / ethanol 3.1: ammonia; N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / tetrahydrofuran 4.1: diethylzinc / ethylene glycol dimethyl ether; dichloromethane / -30 - 20 °C 5.1: isopropyl alcohol / 60 °C 6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / ethyl acetate; acetonitrile / 3 h 7.1: trifluoroacetic anhydride; pyridine / tetrahydrofuran / 0.5 h / 0 °C 7.2: 18 h / 20 °C View Scheme

1.1: lithium triethylborohydride / toluene / -70 - -60 °C 2.1: 4-(N,N-dimethlyamino)pyridine; trifluoroacetic anhydride; N-ethyl-N,N-diisopropylamine 3.1: water; lithium hydroxide hydrate / ethanol 4.1: ammonia; N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / tetrahydrofuran 5.1: diethylzinc / ethylene glycol dimethyl ether; dichloromethane / -30 - 20 °C 6.1: isopropyl alcohol / 60 °C 7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / ethyl acetate; acetonitrile / 3 h 8.1: trifluoroacetic anhydride; pyridine / tetrahydrofuran / 0.5 h / 0 °C 8.2: 18 h / 20 °C View Scheme

1.1: 4-(N,N-dimethlyamino)pyridine 2.1: lithium triethylborohydride / toluene / -70 - -60 °C 3.1: 4-(N,N-dimethlyamino)pyridine; trifluoroacetic anhydride; N-ethyl-N,N-diisopropylamine 4.1: water; lithium hydroxide hydrate / ethanol 5.1: ammonia; N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / tetrahydrofuran 6.1: diethylzinc / ethylene glycol dimethyl ether; dichloromethane / -30 - 20 °C 7.1: isopropyl alcohol / 60 °C 8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / ethyl acetate; acetonitrile / 3 h 9.1: trifluoroacetic anhydride; pyridine / tetrahydrofuran / 0.5 h / 0 °C 9.2: 18 h / 20 °C View Scheme

1.1: water; lithium hydroxide hydrate / ethanol 2.1: ammonia; N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / tetrahydrofuran 3.1: diethylzinc / ethylene glycol dimethyl ether; dichloromethane / -30 - 20 °C 4.1: isopropyl alcohol / 60 °C 5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / ethyl acetate; acetonitrile / 3 h 6.1: trifluoroacetic anhydride; pyridine / tetrahydrofuran / 0.5 h / 0 °C 6.2: 18 h / 20 °C View Scheme

1.1: diethylzinc / ethylene glycol dimethyl ether; dichloromethane / -30 - 20 °C 2.1: isopropyl alcohol / 60 °C 3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / ethyl acetate; acetonitrile / 3 h 4.1: trifluoroacetic anhydride; pyridine / tetrahydrofuran / 0.5 h / 0 °C 4.2: 18 h / 20 °C View Scheme

1.1: isopropyl alcohol / 60 °C 2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / ethyl acetate; acetonitrile / 3 h 3.1: trifluoroacetic anhydride; pyridine / tetrahydrofuran / 0.5 h / 0 °C 3.2: 18 h / 20 °C View Scheme

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / ethyl acetate; acetonitrile / 3 h 2.1: trifluoroacetic anhydride; pyridine / tetrahydrofuran / 0.5 h / 0 °C 2.2: 18 h / 20 °C View Scheme