magnesium 1.) THF, 60 deg C, 40 min; 2.) ether, -78 to 5 deg C, overnight; Yield given. Multistep reaction. Yields of byproduct given;

1.1: n-butyllithium / diethyl ether; hexane / 0.5 h / 0 °C / Inert atmosphere 1.2: 1.5 h / 20 °C / Inert atmosphere 2.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 5 h / Reflux; Inert atmosphere 3.1: dichloromethane / 0.08 h / 0 °C / Inert atmosphere 3.2: 12 h / 0 - 20 °C / Inert atmosphere 4.1: dichloro bis(acetonitrile) palladium(II); oxygen; triethylamine; copper dichloride / methanol / 18 h / 60 °C / 760.05 Torr / Cooling with liquid nitrogen View Scheme