(R)-1,4-苯并二噁烷-2-甲酸合成路线 （共 7 条）
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran 3 h;
参考文献
Rouf, Abdul; Gupta, Pankaj; Aga, Mushtaq A.; Kumar, Brijesh; Chaubey, Asha; Parshad, Rajinder; Taneja, Subhash C.
Tetrahedron Asymmetry, 2012 , vol. 23, # 22-23 p. 1615 - 1623
反应条件
sulfuric acid; acetic acid in water T=110°C; 15 h;
参考文献
Tomiyama; Wakabayashi; Yokota
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996
参考文献
Journal of the American Chemical Society, , vol. 77, p. 5373
反应条件
1: 85 percent / K2CO3 / acetone / 12 h / Heating 2: 98 percent / HOAc, conc. H2SO4 / H2O / 15 h / 110 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 8 p. 1988 - 1996
反应条件
T=150°C; anschl. mit methanol. KOH;
参考文献
Journal of the Chemical Society, , p. 2136,2138
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 1 p. 49 - 57
反应条件
1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 0.17 h / 0 °C
2: trifluoroacetic acid / dichloromethane / 1 h / 0 °C
View Scheme
参考文献
Rouf, Abdul; Aga, Mushtaq A.; Kumar, Brijesh; Taneja, Subhash Chandra
Tetrahedron Letters, 2013 , vol. 54, # 48 p. 6420 - 6422
