4-乙基-5-硝基-2-吡啶胺合成路线 （共 5 条）
反应条件
1: 54 percent / hydrobromic acid; Br2 / 1.5 h / cooling 2: 90 percent / hydrogen / nickel / tetrahydrofuran / 18 h 3: acetic acid; sodium nitrite / H2O / 24 h / 20 °C View Scheme
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Viraj B.; Woods, Keith; Luo, Yan; Liu, Xuesong; Guan, Ran; Klinghofer, Vered; Johnson, Eric F.; Stoll, Vincent S.; Mamo, Mulugeta; Li, Qun; Rosenberg, Saul H.; Giranda, Vincent L.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 6 p. 2441 - 2452
反应条件
1: NaNH2; mineral oil / 145 °C
2: H2SO4; concentrated HNO3
View Scheme
参考文献
Hansch et al.
Journal of Organic Chemistry, 1958 , vol. 23, p. 1924
反应条件
sulfuric acid; nitric acid
参考文献
Hansch et al.
Journal of Organic Chemistry, 1958 , vol. 23, p. 1924
反应条件
hydrogen bromide; bromine
1.5 h; cooling;
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Viraj B.; Woods, Keith; Luo, Yan; Liu, Xuesong; Guan, Ran; Klinghofer, Vered; Johnson, Eric F.; Stoll, Vincent S.; Mamo, Mulugeta; Li, Qun; Rosenberg, Saul H.; Giranda, Vincent L.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 6 p. 2441 - 2452
反应条件
1: 54 percent / hydrobromic acid; Br2 / 1.5 h / cooling
2: 90 percent / hydrogen / nickel / tetrahydrofuran / 18 h
View Scheme
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Viraj B.; Woods, Keith; Luo, Yan; Liu, Xuesong; Guan, Ran; Klinghofer, Vered; Johnson, Eric F.; Stoll, Vincent S.; Mamo, Mulugeta; Li, Qun; Rosenberg, Saul H.; Giranda, Vincent L.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 6 p. 2441 - 2452
