1-溴-3-[4'-溴(1,1'-联苯)-4-基]-1,2,3,4-四氢萘合成路线 （共 8 条）
反应条件
phosphorus tribromide in dichloromethane
T=0°C;
参考文献
Van Heerden, Pieter S.; Bezuidenhoudt, Barend C. B.; Ferreira, Daneel
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 8 p. 1141 - 1146
反应条件
1: 88 percent / AlCl3 / CH2Cl2 / 16 h / -10 °C
2: 95 percent / Zn; I2 / benzene / 1 h / Heating
3: 85 percent / Et3SiH; TFA; BF3*Et2O / CH2Cl2 / 8 h / Heating
4: 93 percent / aq. KOH / 8 h / Heating
5: 80 percent / polyphosphoric acid / 1 h / 80 °C
6: 85 percent / NaBH4 / ethanol / 2 h / 20 °C
7: PBr3 / CH2Cl2 / 1 h / -10 °C
View Scheme
参考文献
Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531
反应条件
1: 95 percent / Zn; I2 / benzene / 1 h / Heating
2: 85 percent / Et3SiH; TFA; BF3*Et2O / CH2Cl2 / 8 h / Heating
3: 93 percent / aq. KOH / 8 h / Heating
4: 80 percent / polyphosphoric acid / 1 h / 80 °C
5: 85 percent / NaBH4 / ethanol / 2 h / 20 °C
6: PBr3 / CH2Cl2 / 1 h / -10 °C
View Scheme
参考文献
Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531
反应条件
1: 85 percent / NaBH4 / ethanol / 2 h / 20 °C
2: PBr3 / CH2Cl2 / 1 h / -10 °C
View Scheme
参考文献
Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531
反应条件
1: 88 percent / AlCl3 / CH2Cl2 / 16 h / -10 °C
2: 95 percent / Zn; I2 / benzene / 1 h / Heating
3: 85 percent / Et3SiH; TFA; BF3*Et2O / CH2Cl2 / 8 h / Heating
4: 93 percent / aq. KOH / 8 h / Heating
5: 80 percent / polyphosphoric acid / 1 h / 80 °C
6: 85 percent / NaBH4 / ethanol / 2 h / 20 °C
7: PBr3 / CH2Cl2 / 1 h / -10 °C
View Scheme
参考文献
Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531
反应条件
1: 93 percent / aq. KOH / 8 h / Heating
2: 80 percent / polyphosphoric acid / 1 h / 80 °C
3: 85 percent / NaBH4 / ethanol / 2 h / 20 °C
4: PBr3 / CH2Cl2 / 1 h / -10 °C
View Scheme
参考文献
Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531
反应条件
1: 80 percent / polyphosphoric acid / 1 h / 80 °C
2: 85 percent / NaBH4 / ethanol / 2 h / 20 °C
3: PBr3 / CH2Cl2 / 1 h / -10 °C
View Scheme
参考文献
Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531
反应条件
1: 85 percent / Et3SiH; TFA; BF3*Et2O / CH2Cl2 / 8 h / Heating
2: 93 percent / aq. KOH / 8 h / Heating
3: 80 percent / polyphosphoric acid / 1 h / 80 °C
4: 85 percent / NaBH4 / ethanol / 2 h / 20 °C
5: PBr3 / CH2Cl2 / 1 h / -10 °C
View Scheme
参考文献
Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531
