4-溴- 1 -叔丁基-1H -吡唑合成路线 （共 3 条）
反应条件
N-bromosuccinmide in dichloromethane T=0 - 20°C; Industry scale; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED; ATKINSON, Francis Louis; BARKER, Michael David; DOUAULT, Clement; GARTON, Neil Stuart; LIDDLE, John; PATEL, Vipulkumar Kantibhai; PRESTON, Alexander George Steven; WILSON, David Matthew
Patent: WO2011/134971 A1, 2011 ;
Location in patent: Page/Page column 16; 17; 72 ;
WO 2011/134971 A1
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane 15 h; Reflux;
参考文献
F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; DO, Steven; HU, Huiyong; KOLESNIKOV, Aleksandr; TSUI, Vickie, H.; WANG, Xiaojing
Patent: WO2014/1377 A1, 2014 ;
Location in patent: Page/Page column 104; 105 ;
反应条件
1: 4-bromo-1-(1,1-dimethylethyl)-1H-pyrazole With n-butyllithium in tetrahydrofuran T=-85 - -75°C; 1 h; Industry scale; 2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran 3 h; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED; Atkinson, Francis Louis; Barker, Michael David; Douault, Clement; Garton, Neil Stuart; Liddle, John; Patel, Vipulkumar Kantibhai; Preston, Alexander George Steven; Wilson, David Matthew
Patent: US2013/40984 A1, 2013 ;
Location in patent: Paragraph 0484-0485 ;
