7-溴-4,5-二氢-1H-吡啶并[2,3-e][1,4]二氮杂革-2(3H)-酮合成路线 （共 4 条）
反应条件
sodium hydride in dimethyl sulfoxide
T=20°C; 27 h;
参考文献
AFFINIUM PHARMACEUTICALS, INC.
Patent: WO2004/52890 A1, 2004 ;
Location in patent: Page 52-53; 105 ;
WO 2004/052890 A1
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / |Reflux
2: acetic acid; bromine / 3 h / 20 - 35 °C
3: hydrogen bromide / water / 16 h / |Reflux
4: triethylamine / N,N-dimethyl-formamide / 5 h / 20 - 35 °C
5: sodium hydride / dimethyl sulfoxide / 5 h / 20 - 35 °C
View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; MAHADARI, Muni Kumar; KOTTAM, Chandrashekar Reddy; ABD RAHMAN, Noorsaadah; YUSOF, Rohana
Patent: WO2013/80222 A1, 2013 ;
反应条件
1: acetic acid; bromine / 3 h / 20 - 35 °C
2: hydrogen bromide / water / 16 h / |Reflux
3: triethylamine / N,N-dimethyl-formamide / 5 h / 20 - 35 °C
4: sodium hydride / dimethyl sulfoxide / 5 h / 20 - 35 °C
View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; MAHADARI, Muni Kumar; KOTTAM, Chandrashekar Reddy; ABD RAHMAN, Noorsaadah; YUSOF, Rohana
Patent: WO2013/80222 A1, 2013 ;
反应条件
1: hydrogen bromide / water / 16 h / |Reflux
2: triethylamine / N,N-dimethyl-formamide / 5 h / 20 - 35 °C
3: sodium hydride / dimethyl sulfoxide / 5 h / 20 - 35 °C
View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; MAHADARI, Muni Kumar; KOTTAM, Chandrashekar Reddy; ABD RAHMAN, Noorsaadah; YUSOF, Rohana
Patent: WO2013/80222 A1, 2013 ;
