N-甲氧基琥珀酰-丙酰氨-丙酰氨-脯酰氨-缬氨酸对硝基酰苯胺合成路线 （共 7 条）
反应条件
1-PhCH2NHCO-3,3-Et2-4-(1-Ph-ethylideneaminoxy)azetidin-2-one; human leukocyte elastase EC 3.4.21.37 in phosphate buffer; dimethyl sulfoxide T=37°C; Hydrolysis; pH=7.8; 0.5 h; Enzymatic reaction; Kinetics; Further Variations:Reagents;
参考文献
Li, Yi; Yang, Qingliang; Dou, Dengfeng; Alliston, Kevin R.; Groutas, William C.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 2 p. 692 - 698
反应条件
in methanol; diethyl ether
0.0833333 h; Ambient temperature;
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
反应条件
1: 71 percent / 24 h / Ambient temperature
2: 69 percent / 1N NaOH / dioxane / 24 h / Ambient temperature
3: 73 percent / N-ethylmorpholine, isobutyl chloroformate / tetrahydrofuran / 1 h / -15 - 20 °C
4: HBr / trifluoroacetic acid
5: 70 percent / acetonitrile / 24 h
6: 88 percent / methanol; diethyl ether / 0.08 h / Ambient temperature
View Scheme
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
反应条件
1: 69 percent / 1N NaOH / dioxane / 24 h / Ambient temperature
2: 73 percent / N-ethylmorpholine, isobutyl chloroformate / tetrahydrofuran / 1 h / -15 - 20 °C
3: HBr / trifluoroacetic acid
4: 70 percent / acetonitrile / 24 h
5: 88 percent / methanol; diethyl ether / 0.08 h / Ambient temperature
View Scheme
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
反应条件
1: HBr / trifluoroacetic acid
2: 70 percent / acetonitrile / 24 h
3: 88 percent / methanol; diethyl ether / 0.08 h / Ambient temperature
View Scheme
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
反应条件
1: 73 percent / N-ethylmorpholine, isobutyl chloroformate / tetrahydrofuran / 1 h / -15 - 20 °C
2: HBr / trifluoroacetic acid
3: 70 percent / acetonitrile / 24 h
4: 88 percent / methanol; diethyl ether / 0.08 h / Ambient temperature
View Scheme
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
反应条件
1: 70 percent / acetonitrile / 24 h
2: 88 percent / methanol; diethyl ether / 0.08 h / Ambient temperature
View Scheme
参考文献
Martynov, V. F.; Leont'eva, L. I.; Sorochinskaya, E. I.; Smirnov, A. O.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 2 p. 430 - 436,384 - 388
