1-(3-氨基-2-羟基-5-甲基苯基)-2,2,2-三氟乙烷酮合成路线 （共 3 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Ford; Knowles; Lunt; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 538 - 549
反应条件
1: 44 percent / conc. HNO3, conc. H2SO4 / -20 °C
2: 57 percent / H2 / 5percent Pd/C / ethanol
View Scheme
参考文献
Ford; Knowles; Lunt; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 538 - 549
反应条件
1: (i) AlCl3, CS2, (ii) /BRN= 3595638/, aq. NH3
2: HNO3, AcOH / CH2Cl2
3: H2 / Pt-C / ethanol
View Scheme
参考文献
May and Baker
Patent: DE2846931 , 1979 ;
Chem.Abstr., 1979 , vol. 91, # 74626
