1: 1.) toluene-p-sulphonic acid, 2.) sodium hydride / 1) CH2Cl2, methanol, 20 deg C, 20 h; 2) CH2Cl2, methanol, ethanol 2: 72 percent / benzoyl chloride / 2 h / 20 °C 3: 75 percent / Et3N, H2 / Pd/C / tetrahydrofuran / Ambient temperature 4: 69 percent / NaHCO3, iodine, potassium iodide / H2O; CH2Cl2 5: 72 percent / H2, Et3N / Adams' platinum oxide / methanol / 0.75 h / 20 °C 6: 56 percent / acetic acid / 20 °C 7: 80 percent / sodium borohydride, Et3N / CHCl3; methanol 8: aq. KOH / 16 h / 25 °C 9: H2O / 37 °C / pH 8.25; cosynthetase; Vmax, t1/2 View Scheme