4-(三氟甲氧基)苯甲醚合成路线 （共 14 条）
反应条件
sulfuric acid; trifluoroacetic acid
参考文献
Hoechst Marion Roussel, Inc.
Patent: US5932571 A1, 1999 ;
US 5932571 A
反应条件
1: 1-methoxy-4-trifluoromethoxybenzene With tert.-butyl lithium in tetrahydrofuran; pentane T=-75°C; 2 h; 2: carbon dioxide in tetrahydrofuran; pentane Further stages.;
参考文献
Castagnetti, Eva; Schlosser, Manfred
Chemistry - A European Journal, 2002 , vol. 8, # 4 p. 799 - 804
反应条件
1: 1-methoxy-4-trifluoromethoxybenzene With N,N,N',N'',N''-pentamethylethylenetriamine; sec.-butyllithium in tetrahydrofuran; hexane T=-75°C; 2 h; 2: carbon dioxide in tetrahydrofuran; hexane
参考文献
Castagnetti, Eva; Schlosser, Manfred
Chemistry - A European Journal, 2002 , vol. 8, # 4 p. 799 - 804
反应条件
1: nitric acid; sulfuric acid / dichloromethane / 0 - 20 °C
2: water; sodium dithionite / tetrahydrofuran / 16 h / 20 °C
View Scheme
参考文献
TETRAPHASE PHARMACEUTICALS, INC.; CHEN, Chi-Li; CLARK, Roger, B.; DENG, Yonghong; PLAMONDON, Louis; SUN, Cuixiang; XIAO, Xiao-Yi
Patent: WO2012/21712 A1, 2012 ;
