1,3-二氮杂螺[4.7]十二烷-2,4-二酮合成路线 （共 9 条）
反应条件
1: aq. NaOH / 72 h / Heating 2: aq. NaOH / dioxane / 12 h / Ambient temperature View Scheme
参考文献
Palacin, Serge; Chin, Donovan N.; Simanek, Eric E.; MacDonald, John C.; Whitesides, George M.; McBride, Mary T.; Palmore, G. Tayhas R.
Journal of the American Chemical Society, 1997 , vol. 119, # 49 p. 11807 - 11816
反应条件
sodium hydroxide Heating;
参考文献
Tsang, Joseph W.; Schmied, Bernhard; Nyfeler, Rolf; Goodman, Murray
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1663 - 1668
反应条件
in ethanol
Bucherer-Lieb reaction; 6 h; Heating;
参考文献
Naydenova, Emilia; Pencheva, Nevena; Popova, Julita; Stoyanov, Neyko; Lazarova, Maria; Aleksiev, Boris
Farmaco, 2002 , vol. 57, # 3 p. 189 - 194
反应条件
1: in ethanol; water
T=60°C; 11 h; Inert atmosphere;
2: With hydrogenchloride in ethanol; water
T=0°C; 15 h;
参考文献
Hayashi, Shigeo; Nakata, Eriko; Morita, Asato; Mizuno, Kunihiko; Yamamura, Kenzo; Kato, Aki; Ohashi, Katsuyo
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 21 p. 7675 - 7699
参考文献
Tiffeneau; Tchoubar; Saiaslambert
Bulletin de la Societe Chimique de France, 1947 , p. 445,448
反应条件
ammonium hydroxide in ethanol; water
Bucherer-Lieb reaction; 6 h; Reflux;
参考文献
Naydenova, Emilia D.; Todorov, Petar T.; Troev, Kolio D.
Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 7 p. 1315 - 1320
反应条件
in ethanol; water
6 h; Heating;
参考文献
Tsang, Joseph W.; Schmied, Bernhard; Nyfeler, Rolf; Goodman, Murray
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1663 - 1668
反应条件
ammonium hydroxide in ethanol
Bucherer-Lieb reaction; 6 h;
参考文献
Naydenova, Emilia D.; Todorov, Petar T.; Topashka-Ancheva, Margarita N.; Momekov, Georgi Ts.; Yordanova, Tsvetelina Z.; Konstantinov, Spiro M.; Troev, Kolio D.
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 6 p. 1199 - 1205
反应条件
1: aq. NaOH / 72 h / Heating
2: HCl / 4 h / Heating
View Scheme
参考文献
Tsang, Joseph W.; Schmied, Bernhard; Nyfeler, Rolf; Goodman, Murray
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1663 - 1668
