2-咪唑-1-基-1-萘-1-基-乙醇合成路线 （共 5 条）
反应条件
sodium tetrahydroborate in methanol
2 h;
参考文献
Wahbi, Y.; Caujolle, R.; Tournaire, C.; Payard, M.; Linas, M. D.; Seguela, J. P.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 12 p. 955 - 962
反应条件
in chloroform; ethyl acetate
参考文献
Syntex (U.S.A.) Inc.
Patent: US4172141 A1, 1979 ;
反应条件
1: dimethylformamide / 1.) 0 deg C, 2 h, 2.) RT, overnight
2: NaBH4 / methanol / 0.5 h / 0 °C
View Scheme
参考文献
Walker; Wallach; Hirschfeld
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 67 - 74
反应条件
1: Br2, AcOH / 2 h / Ambient temperature
2: 30 percent / Et3N / acetonitrile / 4 h / Ambient temperature
3: 75 percent / NaBH4 / methanol / 2 h
View Scheme
参考文献
Wahbi, Y.; Caujolle, R.; Tournaire, C.; Payard, M.; Linas, M. D.; Seguela, J. P.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 12 p. 955 - 962
反应条件
1: 30 percent / Et3N / acetonitrile / 4 h / Ambient temperature
2: 75 percent / NaBH4 / methanol / 2 h
View Scheme
参考文献
Wahbi, Y.; Caujolle, R.; Tournaire, C.; Payard, M.; Linas, M. D.; Seguela, J. P.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 12 p. 955 - 962
