2-氟-3,4-二氢-1(2H)-萘酮合成路线 （共 30 条）
反应条件
triethylamine in cyclohexane T=30°C; 15 h; Irradiation;
参考文献
Sket, B.; Zupancic, N.; Zupan, M.
Journal of Fluorine Chemistry, 1989 , vol. 45, p. 313 - 321
反应条件
sulfuric acid; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in methanol
T=50°C; 16 h; Inert atmosphere;
参考文献
Liu, Jack; Chan, Johann; Bryant, Craig M.; Duspara, Petar A.; Lee, Ernest E.; Powell, David; Yang, Hua; Liu, Ziping; Walpole, Chris; Roberts, Edward; Batey, Robert A.
Tetrahedron Letters, 2012 , vol. 53, # 24 p. 2971 - 2975
反应条件
1: 1-(3,4-dihydro-1-naphthyl)pyrrolidine in tetrahydrofuran
T=-50°C; 0.5 h;
2: benzo[h]quinolinyl(tetrapyrazolylborate)palladium(IV)fluoride trifluoromethanesulfonate in tetrahydrofuran
T=-50°C; 8 h;
3: With ammonium chloride in tetrahydrofuran; water
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; RITTER, Tobias; LEE, Eunsung; KAMLET, Adam, Seth; POWERS, David; FURUYA, Takeru
Patent: WO2012/24604 A2, 2012 ;
Location in patent: Page/Page column 76-77 ;
反应条件
hydrogenchloride in dichloromethane
T=20°C; 2 h;
参考文献
Verniest, Guido; Van Hende, Eva; Surmont, Riccardo; De Kimpe, Norbert
Organic Letters, 2006 , vol. 8, # 21 p. 4767 - 4770
反应条件
CF3O3S(1-)*C25H20BFN9Pd(1+) in acetone
T=85°C;
参考文献
Brandt, Jochen R.; Lee, Eunsung; Boursalian, Gregory B.; Ritter, Tobias
Chemical Science, 2013 , vol. 5, # 1 p. 169 - 179
反应条件
Genapol LRO; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in water
T=60°C; 1 h;
参考文献
Stavber, Gaj; Zupan, Marko; Jereb, Marjan; Stavber, Stojan
Organic Letters, 2004 , vol. 6, # 26 p. 4973 - 4976
反应条件
CF3O3S(1-)*C25H20BFN9Pd(1+) in tetrahydrofuran
T=-50 - 23°C;
参考文献
Brandt, Jochen R.; Lee, Eunsung; Boursalian, Gregory B.; Ritter, Tobias
Chemical Science, 2013 , vol. 5, # 1 p. 169 - 179
反应条件
tert-butyl hypofluorite in chloroform
T=0°C;
参考文献
Ben-David, Iris; Mishani, Eyal; Rozen, Shlomo
Journal of Organic Chemistry, 1998 , vol. 63, # 14 p. 4632 - 4635
反应条件
tri-tert-butyl phosphine; tetra-n-butylammonium difluorotriphenylsilicate(IV); bis(dibenzylideneacetone)-palladium(0) in toluene
T=90°C; 0.333333 h;
参考文献
Guo, Yong; Twamley, Brendan; Shreeve, Jean'Ne M.
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 8 p. 1716 - 1722
反应条件
in dichloromethane
T=-78°C; 0.0333333 h;
参考文献
Rozen, Shlomo; Hebel, David
Journal of Organic Chemistry, 1990 , vol. 55, # 9 p. 2621 - 2623
