2-氟-3,4-二氢-1(2H)-萘酮合成路线 （共 30 条）
反应条件
sodium hexamethyldisilazane; N-Fluoro-o-benzenedisulfonimide in tetrahydrofuran
1.) -78 deg C, 10 min; -78 to 0 deg C, 0.5 h, 2.) r.t., 2 h;
参考文献
Davis, Franklin A.; Han, Wei; Murphy, Christopher K.
Journal of Organic Chemistry, 1995 , vol. 60, # 15 p. 4730 - 4737
反应条件
tert-butyl hypofluorite in chloroform
T=0°C; 0.5 h;
参考文献
Ben-David, Iris; Mishani, Eyal; Rozen, Shlomo
Journal of Organic Chemistry, 1998 , vol. 63, # 14 p. 4632 - 4635
反应条件
potassium hydroxide in ethanol; water
1.5 h; Reflux;
参考文献
Poisson, Thomas; Oudeyer, Sylvain; Dalla, Vincent; Marsais, Francis; Levacher, Vincent
Synlett, 2008 , # 16 p. 2447 - 2450
反应条件
1: With tri-tert-butyl phosphine; tetra-n-butylammonium difluorotriphenylsilicate(IV); bis(dibenzylideneacetone)-palladium(0) in toluene
T=95°C; Inert atmosphere;
2: With silica gel in toluene
参考文献
Guo, Yong; Tao, Guo-Hong; Blumenfeld, Alex; Shreeve, Jean'ne M.
Organometallics, 2010 , vol. 29, # 7 p. 1818 - 1823
反应条件
XeF2 in acetonitrile
T=20°C; 1 h;
参考文献
Ramsden, Christopher A.; Smith, Rachel G.
Organic Letters, 1999 , vol. 1, # 10 p. 1591 - 1594
反应条件
tri-tert-butyl phosphine; tri-n-butyltin fluoride; bis(dibenzylideneacetone)-palladium(0) in toluene
T=90°C; 10 h;
参考文献
Guo, Yong; Twamley, Brendan; Shreeve, Jean'Ne M.
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 8 p. 1716 - 1722
反应条件
1: With tri-tert-butyl phosphine; tetra-n-butylammonium difluorotriphenylsilicate(IV); bis(dibenzylideneacetone)-palladium(0) in toluene
T=95°C; Inert atmosphere;
2: With silica gel in toluene
参考文献
Guo, Yong; Tao, Guo-Hong; Blumenfeld, Alex; Shreeve, Jean'ne M.
Organometallics, 2010 , vol. 29, # 7 p. 1818 - 1823
反应条件
1: With tri-tert-butyl phosphine; tetra-n-butylammonium difluorotriphenylsilicate(IV); bis(dibenzylideneacetone)-palladium(0) in toluene
T=95°C; Inert atmosphere;
2: With silica gel in toluene
参考文献
Guo, Yong; Tao, Guo-Hong; Blumenfeld, Alex; Shreeve, Jean'ne M.
Organometallics, 2010 , vol. 29, # 7 p. 1818 - 1823
反应条件
tri-tert-butyl phosphine; tetra-n-butylammonium difluorotriphenylsilicate(IV); bis(dibenzylideneacetone)-palladium(0) in toluene
T=90°C; 0.333333 h;
参考文献
Guo, Yong; Twamley, Brendan; Shreeve, Jean'Ne M.
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 8 p. 1716 - 1722
反应条件
1: 71 percent / N-fluorobenzenesulfonimide; potassium carbonate / acetonitrile; dimethylformamide / 0 °C
2: 86 percent / aq. HCl / CH2Cl2 / 2 h / 20 °C
View Scheme
参考文献
Verniest, Guido; Van Hende, Eva; Surmont, Riccardo; De Kimpe, Norbert
Organic Letters, 2006 , vol. 8, # 21 p. 4767 - 4770
