1: benzene; diethyl ether / -10 - -5 °C 2: Rh(OAc)2 / 1 h / Ambient temperature 3: CeCl3*5H2O, NaBH4 / propan-2-ol; H2O 4: pyridine / 0 °C 5: imidazole / dimethylformamide / Ambient temperature 6: 98 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 7: 46 percent / 80percent AcOH / 48 h / Ambient temperature 8: 96 percent / CBr4, bis(1,2-diphenylphosphino)ethane (DIPHOS) / CH2Cl2 / 0.5 h / Ambient temperature 9: 1.) CuI, n-BuLi, 2.) HMPA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, a.) from -78 to 0 deg C, 1 h, b) RT, 1 h 10: 61 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 11: tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 12: LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

1: Rh(OAc)2 / 1 h / Ambient temperature 2: CeCl3*5H2O, NaBH4 / propan-2-ol; H2O 3: pyridine / 0 °C 4: imidazole / dimethylformamide / Ambient temperature 5: 98 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 6: 46 percent / 80percent AcOH / 48 h / Ambient temperature 7: 96 percent / CBr4, bis(1,2-diphenylphosphino)ethane (DIPHOS) / CH2Cl2 / 0.5 h / Ambient temperature 8: 1.) CuI, n-BuLi, 2.) HMPA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, a.) from -78 to 0 deg C, 1 h, b) RT, 1 h 9: 61 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 10: tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 11: LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

1: pyridine / 0 °C 2: imidazole / dimethylformamide / Ambient temperature 3: 98 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 4: 46 percent / 80percent AcOH / 48 h / Ambient temperature 5: 96 percent / CBr4, bis(1,2-diphenylphosphino)ethane (DIPHOS) / CH2Cl2 / 0.5 h / Ambient temperature 6: 1.) CuI, n-BuLi, 2.) HMPA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, a.) from -78 to 0 deg C, 1 h, b) RT, 1 h 7: 61 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 8: tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 9: LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

1: CeCl3*5H2O, NaBH4 / propan-2-ol; H2O 2: pyridine / 0 °C 3: imidazole / dimethylformamide / Ambient temperature 4: 98 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 5: 46 percent / 80percent AcOH / 48 h / Ambient temperature 6: 96 percent / CBr4, bis(1,2-diphenylphosphino)ethane (DIPHOS) / CH2Cl2 / 0.5 h / Ambient temperature 7: 1.) CuI, n-BuLi, 2.) HMPA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, a.) from -78 to 0 deg C, 1 h, b) RT, 1 h 8: 61 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 9: tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 10: LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

1: imidazole / dimethylformamide / Ambient temperature 2: 98 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 3: 46 percent / 80percent AcOH / 48 h / Ambient temperature 4: 96 percent / CBr4, bis(1,2-diphenylphosphino)ethane (DIPHOS) / CH2Cl2 / 0.5 h / Ambient temperature 5: 1.) CuI, n-BuLi, 2.) HMPA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, a.) from -78 to 0 deg C, 1 h, b) RT, 1 h 6: 61 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 7: tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 8: LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

1: 61 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 2: tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 3: LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

1: 46 percent / 80percent AcOH / 48 h / Ambient temperature 2: 96 percent / CBr4, bis(1,2-diphenylphosphino)ethane (DIPHOS) / CH2Cl2 / 0.5 h / Ambient temperature 3: 1.) CuI, n-BuLi, 2.) HMPA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, a.) from -78 to 0 deg C, 1 h, b) RT, 1 h 4: 61 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 5: tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 6: LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

1: 98 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 2: 46 percent / 80percent AcOH / 48 h / Ambient temperature 3: 96 percent / CBr4, bis(1,2-diphenylphosphino)ethane (DIPHOS) / CH2Cl2 / 0.5 h / Ambient temperature 4: 1.) CuI, n-BuLi, 2.) HMPA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, a.) from -78 to 0 deg C, 1 h, b) RT, 1 h 5: 61 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 6: tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 7: LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

1: 96 percent / CBr4, bis(1,2-diphenylphosphino)ethane (DIPHOS) / CH2Cl2 / 0.5 h / Ambient temperature 2: 1.) CuI, n-BuLi, 2.) HMPA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, a.) from -78 to 0 deg C, 1 h, b) RT, 1 h 3: 61 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 4: tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 5: LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme

1: 1.) CuI, n-BuLi, 2.) HMPA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, a.) from -78 to 0 deg C, 1 h, b) RT, 1 h 2: 61 percent / H2, pyridine / Lindlar catalyst / hexane / 10 h / 760 Torr 3: tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 4: LiOH / 1,2-dimethoxy-ethane; H2O / Ambient temperature View Scheme