2-(6-甲氧基萘-2-基)乙腈合成路线 （共 11 条）
反应条件
tris(dibenzylideneacetone)dipalladium (0); ZnF2; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in N,N-dimethyl-formamide T=90°C; 18 h;
参考文献
Wu, Lingyun; Hartwig, John F.
Journal of the American Chemical Society, 2005 , vol. 127, # 45 p. 15824 - 15832
反应条件
tetrabutylammomium bromide in dichloromethane; water T=50°C; 29 h;
参考文献
WO2003/104178 A1, ;
Page 88 ;
反应条件
N-benzyl-N,N,N-triethylammonium chloride in dichloromethane; water 20 h; Heating;
参考文献
McCarthy, James R.; Huffman, John C.
Journal of Organic Chemistry, 1984 , vol. 49, # 25 p. 4995 - 4997
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; water in dimethyl sulfoxide T=130°C; Domino Suzuki coupling and fragmentation reaction; 16 h; Inert atmosphere;
参考文献
Velcicky, Juraj; Soicke, Arne; Steiner, Roland; Schmalz, Hans-Guenther
Journal of the American Chemical Society, 2011 , vol. 133, # 18 p. 6948 - 6951
反应条件
1: ZnCl2, SOCl2 / dioxane / 0.67 h 2: acetonitrile; H2O / 19 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 17 p. 2485 - 2493
反应条件
1: DIBAL / tetrahydrofuran / 18 h / 0 - 20 °C 2: ZnCl2, SOCl2 / dioxane / 0.67 h 3: acetonitrile; H2O / 19 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 17 p. 2485 - 2493
反应条件
in N,N-dimethyl-formamide 3 h; Ambient temperature; Yield given;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 2 p. 428 - 439
反应条件
1: 91.7 percent / NaBH4 / methanol; H2O / 2 h / Ambient temperature 2: gaseous HCl / benzene / 2 h / 60 °C 3: dimethylformamide / 3 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 2 p. 428 - 439
反应条件
1: 70.2 percent / Mg / tetrahydrofuran / rt, 1 h, reflux 6 h 2: 91.7 percent / NaBH4 / methanol; H2O / 2 h / Ambient temperature 3: gaseous HCl / benzene / 2 h / 60 °C 4: dimethylformamide / 3 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 30, # 2 p. 428 - 439
反应条件
sodium hydroxide in methanol; water 40 h; Reflux;
参考文献
Chemical Communications, , vol. 46, # 10 p. 1697 - 1699
