N-叔丁氧羰基-2-氨基茚满-2-羧酸合成路线 （共 7 条）
反应条件
1: With 4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C; 48 h; 2: With hydrogenchloride in water; acetonitrile pH=2;
参考文献
PROZYMEX A/S; PEDERSEN, John; LAURITZEN, Conni
Patent: WO2012/119941 A1, 2012 ;
Location in patent: Page/Page column 110 ;
WO 2012/119941 A1
反应条件
sodium hydroxide in methanol; water T=20°C; Hydrolysis; 24 h;
参考文献
Williams, Lawrence J.; Jagadish; Lyon, Scott R.; Kloster, Robin A.; Carducci, Michael D.; Mash, Eugene A.
Tetrahedron, 1999 , vol. 55, # 50 p. 14281 - 14300
反应条件
1: ammonium carbonate / aq. ethanol / 55 - 60 °C 2: aq. NaOH / 72 h / Heating 3: aq. NaOH / dioxane / 12 h / Ambient temperature View Scheme
参考文献
Journal of the American Chemical Society, , vol. 119, # 49 p. 11807 - 11816
反应条件
1: aq. NaOH / 72 h / Heating 2: aq. NaOH / dioxane / 12 h / Ambient temperature View Scheme
参考文献
Journal of the American Chemical Society, , vol. 119, # 49 p. 11807 - 11816
反应条件
1: 90 percent / NaHCO3; NaCl / H2O; CH2Cl2 / 2 h / Heating 2: 93 percent / NaOH / H2O; methanol / 24 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 55, # 50 p. 14281 - 14300
反应条件
1: 90 percent / NaHCO3; NaCl / H2O; CH2Cl2 / 2 h / Heating 2: 93 percent / NaOH / H2O; methanol / 24 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 55, # 50 p. 14281 - 14300
反应条件
1: 3.40 g / sodium bis(trimethylsilyl)amide / tetrahydrofuran / -78 - 20 °C 2: TFA / tetrahydrofuran; H2O / 1 h 3: 90 percent / NaHCO3; NaCl / H2O; CH2Cl2 / 2 h / Heating 4: 93 percent / NaOH / H2O; methanol / 24 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 55, # 50 p. 14281 - 14300
