(S)-2-叔丁氧基羰基氨基庚酸合成路线 （共 9 条）
反应条件
sodium hydroxide in 1,4-dioxane
T=20°C;
参考文献
Catalano, John G; Deaton, David N; Furfine, Eric S; Hassell, Annie M; McFadyen, Robert B; Miller, Aaron B; Miller, Larry R; Shewchuk, Lisa M; Willard Jr., Derril H; Wright, Lois L
Bioorganic and medicinal chemistry letters, 2004 , vol. 14, # 1 p. 275 - 278
反应条件
1: 2-amino-6-bromo-hexanoic acid With sodium hydroxide in 1,4-dioxane; water
T=0°C; 0.166667 h;
2: di-tert-butyl dicarbonate in 1,4-dioxane; water
T=0 - 20°C;
参考文献
Gupta, Praveer K.; Reid, Robert C.; Liu, Ligong; Lucke, Andrew J.; Broomfield, Steve A.; Andrews, Melanie R.; Sweet, Matthew J.; Fairlie, David P.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 23 p. 7067 - 7070
反应条件
1: 73 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran / 0 °C
2: 74 percent / PPh3, diethylazodicarboxylate / tetrahydrofuran / 0 °C
3: 29 percent / CuBr*Me2S / tetrahydrofuran; toluene / 18 h / -20 °C
4: 1.) CF3CO2H; 2.) 6N HCl
View Scheme
参考文献
Baldwin, Jack E.; Farthing, Christopher N.; Russell, Andrew T.; Schofield, Christopher J.; Spivey, Alan C.
Tetrahedron Letters, 1996 , vol. 37, # 21 p. 3761 - 3764
反应条件
1: 96 percent / LiOH / H2O; dioxane
2: 19 percent / BF3*Et2O / acetone; cyclohexane / 12 h
3: 79 percent / CuBr*Me2S / toluene / 16 h / -40 °C
4: trifluoroacetic acid
View Scheme
参考文献
Baldwin, Jack E.; Farthing, Christopher N.; Russell, Andrew T.; Schofield, Christopher J.; Spivey, Alan C.
Tetrahedron Letters, 1996 , vol. 37, # 21 p. 3761 - 3764
反应条件
1: 74 percent / PPh3, diethylazodicarboxylate / tetrahydrofuran / 0 °C
2: 29 percent / CuBr*Me2S / tetrahydrofuran; toluene / 18 h / -20 °C
3: 1.) CF3CO2H; 2.) 6N HCl
View Scheme
参考文献
Baldwin, Jack E.; Farthing, Christopher N.; Russell, Andrew T.; Schofield, Christopher J.; Spivey, Alan C.
Tetrahedron Letters, 1996 , vol. 37, # 21 p. 3761 - 3764
反应条件
1: 29 percent / CuBr*Me2S / tetrahydrofuran; toluene / 18 h / -20 °C
2: 1.) CF3CO2H; 2.) 6N HCl
View Scheme
参考文献
Baldwin, Jack E.; Farthing, Christopher N.; Russell, Andrew T.; Schofield, Christopher J.; Spivey, Alan C.
Tetrahedron Letters, 1996 , vol. 37, # 21 p. 3761 - 3764
反应条件
1: 79 percent / CuBr*Me2S / toluene / 16 h / -40 °C
2: trifluoroacetic acid
View Scheme
参考文献
Baldwin, Jack E.; Farthing, Christopher N.; Russell, Andrew T.; Schofield, Christopher J.; Spivey, Alan C.
Tetrahedron Letters, 1996 , vol. 37, # 21 p. 3761 - 3764
反应条件
hydrogenchloride; trifluoroacetic acid
Multistep reaction;
参考文献
Baldwin, Jack E.; Farthing, Christopher N.; Russell, Andrew T.; Schofield, Christopher J.; Spivey, Alan C.
Tetrahedron Letters, 1996 , vol. 37, # 21 p. 3761 - 3764
反应条件
trifluoroacetic acid
参考文献
Baldwin, Jack E.; Farthing, Christopher N.; Russell, Andrew T.; Schofield, Christopher J.; Spivey, Alan C.
Tetrahedron Letters, 1996 , vol. 37, # 21 p. 3761 - 3764
