barium dihydroxide in ethanol; water Ambient temperature;

1: 86 percent / 2 N NaOH / dioxane; H2O / 0.5 h / 0 - 5 °C 2: 99 percent / SOCl2 / benzene / 2 h / Heating 3: 89 percent / (i-Pr)2NEt / dioxane; H2O 4: Et3N / dimethylformamide; dioxane / 1 h / -10 °C 5: Et3N / dimethylformamide; dioxane / 2 h / 25 °C 6: H2 / 5percent Pd/C / dioxane / 20 h / Ambient temperature 7: N,N-dimethyl-acetamide / 120 h / 25 °C View Scheme

1: 89 percent / (i-Pr)2NEt / dioxane; H2O 2: Et3N / dimethylformamide; dioxane / 1 h / -10 °C 3: Et3N / dimethylformamide; dioxane / 2 h / 25 °C 4: H2 / 5percent Pd/C / dioxane / 20 h / Ambient temperature 5: N,N-dimethyl-acetamide / 120 h / 25 °C View Scheme

1: 99 percent / SOCl2 / benzene / 2 h / Heating 2: 89 percent / (i-Pr)2NEt / dioxane; H2O 3: Et3N / dimethylformamide; dioxane / 1 h / -10 °C 4: Et3N / dimethylformamide; dioxane / 2 h / 25 °C 5: H2 / 5percent Pd/C / dioxane / 20 h / Ambient temperature 6: N,N-dimethyl-acetamide / 120 h / 25 °C View Scheme

1: 89 percent / (i-Pr)2NEt / dioxane; H2O 2: Et3N / dimethylformamide; dioxane / 1 h / -10 °C 3: Et3N / dimethylformamide; dioxane / 2 h / 25 °C 4: H2 / 5percent Pd/C / dioxane / 20 h / Ambient temperature 5: N,N-dimethyl-acetamide / 120 h / 25 °C View Scheme

1: Et3N / dimethylformamide; dioxane / 1 h / -10 °C 2: Et3N / dimethylformamide; dioxane / 2 h / 25 °C 3: H2 / 5percent Pd/C / dioxane / 20 h / Ambient temperature 4: N,N-dimethyl-acetamide / 120 h / 25 °C View Scheme

1: H2 / 5percent Pd/C / dioxane / 20 h / Ambient temperature 2: N,N-dimethyl-acetamide / 120 h / 25 °C View Scheme

1: 1.) diethyl phosphorocyanidate, Et3N, 2.) Et3N / 1.) DMF, 80 deg C, 2 min, 2.) DMF, 80 deg C, 2 h 2: 88 percent / Ba(OH)2*8H2O / ethanol; H2O / Ambient temperature View Scheme

in N,N-dimethyl acetamide T=25°C; 120 h; Yield given;