7-甲氧基-4-氧代-1,4-二氢喹啉-3-羧酸乙酯合成路线 （共 9 条）
反应条件
1: With hydrogenchloride; sodium hydroxide in methanol T=2.5°C; Reflux; 2: T=250 - 260°C;
参考文献
Yang, Donglai; Arifhodzic, Lejla; Ganellin, C. Robin; Jenkinson, Donald H.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 907 - 923
反应条件
1.1: sodium hydroxide; hydrogenchloride / methanol / 2.5 °C / |Reflux 1.2: Dowtherm-A / 250 - 260 °C 2.1: trichlorophosphate; ammonium hydroxide / |Reflux View Scheme
参考文献
Yang, Donglai; Arifhodzic, Lejla; Ganellin, C. Robin; Jenkinson, Donald H.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 907 - 923
反应条件
trichlorophosphate in 1,4-dioxane T=120°C; 1 h;
参考文献
Zhang, Yiqun; Guiguemde, W. Armand; Sigal, Martina; Zhu, Fangyi; Connelly, Michele C.; Nwaka, Solomon; Guy, R. Kiplin
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 7 p. 2756 - 2766
反应条件
1: T=100°C; 3 h;
2: in dowtherm A
0.5 h; Heating / reflux;
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2005/47279 A1, 2005 ;
Location in patent: Page/Page column 53-54 ;
WO 2005/047279 A1
反应条件
in diphenylether
T=240 - 250°C; 0.5 h; Yield given;
参考文献
Mozek; Sket
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1293 - 1295
反应条件
1: 1 h / 110 - 120 °C
2: diphenyl ether / 0.5 h / 240 - 250 °C
View Scheme
参考文献
Mozek; Sket
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1293 - 1295
反应条件
1: 1 h / 110 - 120 °C
2: diphenyl ether / 0.5 h / 240 - 250 °C
View Scheme
参考文献
Mozek; Sket
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1293 - 1295
反应条件
1: 145 - 155 °C
2: Dowtherm-A / ethanol / 250 - 260 °C
View Scheme
参考文献
Yang, Donglai; Arifhodzic, Lejla; Ganellin, C. Robin; Jenkinson, Donald H.
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 907 - 923
反应条件
1: 1.) TlOEt / 1.) ethanol, Rt, 2 h; 2.) without solvent, 70 - 80 deg C, 4 h
2: NaOH / H2O / 2 h / 90 °C
View Scheme
参考文献
Tamura; Fujita; Chen; et al.
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 3 p. 739 - 743
