4-氧代-1,4-二氢喹啉-3-甲腈合成路线 （共 9 条）
反应条件
trichlorophosphate Heating;
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
反应条件
hydrogenchloride; sodium methylate in water; toluene; acetonitrile
参考文献
American Cyanamid Company
Patent: US6384051 B1, 2002 ;
反应条件
1: With sodium methylate in toluene
18 h; Heating / reflux;
2: With hydrogenchloride in water; toluene
pH=3;
参考文献
Wyeth Holdings Corporation
Patent: EP973746 B1, 2003 ;
Location in patent: Page/Page column 41 ;
EP 0973746 B1
反应条件
in diphenylether
T=265°C; Gould-Jacobs reaction; 2 h;
参考文献
Cernuchova, Petra; Vo-Thanh, Giang; Milata, Viktor; Loupy, Andre
Heterocycles, 2004 , vol. 64, p. 177 - 191
参考文献
Lilly Industries Limited
Patent: US4390541 A1, 1983 ;
反应条件
1: in tetrahydrofuran
T=-78°C;
2: With acetic acid
T=20°C;
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
反应条件
1.1: Heating
2.1: tetrahydrofuran / -78 °C
2.2: AcOH / 20 °C
View Scheme
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
反应条件
1: 93 percent / 0.03 h / 70 °C / microwave irradiation
2: 66 percent / diphenyl ether / 2 h / 265 °C
View Scheme
参考文献
Cernuchova, Petra; Vo-Thanh, Giang; Milata, Viktor; Loupy, Andre
Heterocycles, 2004 , vol. 64, p. 177 - 191
反应条件
thermal Gould-Jacobs cyclization;
参考文献
Osornio, Yazmin M.; Miranda, Luis D.; Cruz-Almanza, Raymundo; Muchowski, Joseph M.
Tetrahedron Letters, 2004 , vol. 45, # 13 p. 2855 - 2858
