1,4-二氢-8-甲氧基-4-氧代-3-喹啉甲腈合成路线 （共 6 条）
反应条件
1: acetonitrile With n-butyllithium in tetrahydrofuran
T=-78°C; 0.416667 h;
2: 2-(dimethylamino-methyleneamino)-3-methoxy-benzoic acid methyl ester in tetrahydrofuran; hexane
T=-78°C; 1 h;
参考文献
Wyeth Holdings Corporation
Patent: EP973746 B1, 2003 ;
Location in patent: Page/Page column 85 ;
EP 0973746 B1
反应条件
n-butyllithium; acetic acid in tetrahydrofuran
参考文献
American Cyanamid Company
Patent: US6002008 A1, 1999 ;
US 6002008 A
反应条件
1: in tetrahydrofuran
T=-78°C;
2: With acetic acid
T=20°C;
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
反应条件
1.1: Heating
2.1: tetrahydrofuran / -78 °C
2.2: AcOH / 20 °C
View Scheme
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
反应条件
sodium carbonate in N,N-dimethyl-formamide
参考文献
American Cyanamid Company
Patent: US6288082 B1, 2001 ;
反应条件
trichlorophosphate; N,N-dimethyl-formamide
0.5 h; Heating / reflux;
参考文献
Wyeth Holdings Corporation
Patent: EP973746 B1, 2003 ;
Location in patent: Page/Page column 85 ;
EP 0973746 B1
