12-(四氢-2H-吡喃-2-基氧基)-1-十二碳炔合成路线 （共 50 条）
反应条件
1: LiNH2 / liquid ammonia 2: p-TsOH / methanol 3: 87 percent / H2 / P2Ni View Scheme
参考文献
Mithran, S.; Mamdapur, V. R.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 1-11 p. 755 - 756
反应条件
1: 1.) LiNH2, liquid NH3 / 1.) -33 deg C, 2 h, 2.) THF, -33 deg C, 0.5 h 2: H2 / Pd/C / ethyl acetate / 12 h 3: conc. HCl / ethyl acetate / 4 h / Ambient temperature View Scheme
参考文献
Rao, A. V. Rama; Ravichandran, K.; Reddy, N. Laxma
Synthetic Communications, 1984 , vol. 14, # 8 p. 779 - 786
反应条件
1: 1) Li, FeCl3, NH3 / 1) -35 deg C, 1 h, 2) THP, DMSO, -40 deg C, 2 h 2: 3.0 g / TsOH / methanol; H2O / 20 h View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Gaudenzi, Loretta; Quirici, Maria Grazia
Gazzetta Chimica Italiana, 1980 , vol. 110, # 4 p. 237 - 246
反应条件
1: 1) Li, FeCl3, NH3 / 1) -35 deg C, 1 h, 2) THP, DMSO, -40 deg C, 2 h 2: 3.0 g / TsOH / methanol; H2O / 20 h 3: LiAlH4 / tetrahydrofuran; bis-(2-methoxy-ethyl) ether / 36 h / 140 °C 4: 1.3 g / pyridine / 24 h / Ambient temperature View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Gaudenzi, Loretta; Quirici, Maria Grazia
Gazzetta Chimica Italiana, 1980 , vol. 110, # 4 p. 237 - 246
反应条件
1: 1) Li, FeCl3, NH3 / 1) -35 deg C, 1 h, 2) THP, DMSO, -40 deg C, 2 h 2: 3.0 g / TsOH / methanol; H2O / 20 h 3: LiAlH4 / tetrahydrofuran; bis-(2-methoxy-ethyl) ether / 36 h / 140 °C View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Gaudenzi, Loretta; Quirici, Maria Grazia
Gazzetta Chimica Italiana, 1980 , vol. 110, # 4 p. 237 - 246
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=0 - 20°C; 24 h;
参考文献
Carballeira, Nestor M.; Montano, Nashbly; Cintron, Gabriel A.; Marquez, Carmary; Rubio, Celia Fernandez; Prada, Christopher Fernandez; Balana-Fouce, Rafael
Chemistry and Physics of Lipids, 2011 , vol. 164, # 2 p. 113 - 117
反应条件
in dimethyl sulfoxide
T=5°C; 3.16667 h;
参考文献
IC VEC LIMITED; THIA MEDICA AS
Patent: WO2004/854 A1, 2003 ;
Location in patent: Page 86 ;
反应条件
pyridinium p-toluenesulfonate in chloroform
6 h; Ambient temperature;
参考文献
Rao, A. V. Rama; Ravichandran, K.; Reddy, N. Laxma
Synthetic Communications, 1984 , vol. 14, # 8 p. 779 - 786
反应条件
in dimethyl sulfoxide
12 h;
参考文献
Rezanka, Tomas; Nedbalova, Linda; Sigler, Karel
Phytochemistry, 2008 , vol. 69, # 16 p. 2849 - 2855
反应条件
18-crown-6 ether; potassium tert-butylate in hexane
T=20 - 65°C; 14 h;
参考文献
Csuk, Rene; Niesen, Anja
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2004 , vol. 59, # 8 p. 934 - 942
