12-(四氢-2H-吡喃-2-基氧基)-1-十二碳炔合成路线 （共 50 条）
反应条件
pyridinium p-toluenesulfonate in ethanol
T=70°C; 3 h;
参考文献
Ranganathan, S.; Maniktala, Vibha; Kumar, Raaj; Singh, G. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1197 - 1207
反应条件
n-butyllithium
1.) hexane, HMPT, 0 deg C, 30 min, 2.) 20 deg C, 12 h; Multistep reaction;
参考文献
IC VEC LIMITED; THIA MEDICA AS
Patent: WO2004/854 A1, 2003 ;
Location in patent: Page 87 ;
反应条件
ammonia; iron(III) chloride; lithium
1) -35 deg C, 1 h, 2) THP, DMSO, -40 deg C, 2 h; Multistep reaction;
参考文献
Odinokov; Botsman; Gladysheva
Chemistry of Natural Compounds, 1996 , vol. 32, # 3 p. 381 - 383
反应条件
1: 1.) (C2H5)2ZrHCl, 2.) I2 / 1.) benzene, 2.) benzene
2: 1.) (C2H5)2ZrHCl, 2.) Pd(PPh3)4 / 1.) benzene, 2.) THF
3: aq. acid / methanol
4: PCC / CH2Cl2
View Scheme
参考文献
Michelot, Didier
Synthesis, 1983 , # 2 p. 130 - 134
反应条件
lithium amide in ammonia
参考文献
Mithran, S.; Mamdapur, V. R.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 1-11 p. 755 - 756
反应条件
1: LiNH2 / liquid ammonia
2: p-TsOH / methanol
View Scheme
参考文献
Mithran, S.; Mamdapur, V. R.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 1-11 p. 755 - 756
反应条件
lithium amide
1.) NH3 (liquid), THF, 3 h, 2.) 1 h; Yield given. Multistep reaction;
参考文献
Ranganathan, S.; Maniktala, V.; Kumar, Raaj
Synthetic Communications, 1982 , vol. 12, # 12 p. 959 - 966
反应条件
1: 1.) n-BuLi / 1) THF; 2) HMPT, THF, below 25 deg C, 0.5 h
2: 100 percent / PPTS / ethanol / 3 h / 70 °C
View Scheme
参考文献
Yadav, J. S.; Balakrishnan, Kamalam; Sivadasan, Latha
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 1-11 p. 297 - 302
反应条件
1: 2-(dodec-1-ynyl-1-oxy)tetrahydro-2H-pyran With ethylmagnesium bromide in tetrahydrofuran
T=70°C; 1 h;
2: formaldehyd in tetrahydrofuran
T=70°C; 2 h;
参考文献
Grodner, Jacek
Synthetic Communications, 2006 , vol. 36, # 7 p. 919 - 924
反应条件
1: 1.) n-BuLi / 1) THF; 2) HMPT, THF, below 25 deg C, 0.5 h
2: AcOH
3: H2
View Scheme
参考文献
Ranganathan, S.; Maniktala, V.; Kumar, Raaj
Synthetic Communications, 1982 , vol. 12, # 12 p. 959 - 966
