1,4,8,11-四[(4-甲基苯基)磺酰基]-1,4,8,11-四氮杂环十四烷合成路线 （共 10 条）
反应条件
1: With sulfuric acid T=100°C; 48 h; 2: With sodium hydroxide in water
参考文献
Beijing Molecule Science and Technology Co., Ltd.
Patent: EP2163553 A1, 2010 ;
Location in patent: Page/Page column 18-19 ;
反应条件
sodium hydroxide; tetra-(n-butyl)ammonium iodide in water; toluene
9 h; Heating;
参考文献
Luk'yanenko, N.G.; Basok, S.S.; Filonova, L.K.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, p. 1562 - 1571
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 8 p. 1731 - 1742
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=110°C; 8 h;
参考文献
Meunier, I.; Mishra, A. K.; Hanquet, B.; Cocolios, P.; Guilard, R.
Canadian Journal of Chemistry, 1995 , vol. 73, # 5 p. 685 - 695
反应条件
1: 91 percent / sodium hydroxide / H2O / 1.) 1 hr., 5 deg C, 2.) r.t., 3 hrs.
2: 85 percent / tetrabutylammonium iodide, sodium hydroxide (50 percent) / toluene; H2O / 9 h / Heating
View Scheme
参考文献
Luk'yanenko, N.G.; Basok, S.S.; Filonova, L.K.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, p. 1562 - 1571
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 8 p. 1731 - 1742
反应条件
in N,N-dimethyl-formamide
参考文献
Pisareva, S. A.; Bel'skii, F. I.; Medved', T. Ya.; Kabachnik, M. I.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1987 , vol. 36, # 2 p. 372 - 376
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1987 , # 2 p. 413 - 417
反应条件
1: 74.6 percent / aq. NaOH / diethyl ether / 1 h / Ambient temperature
2: 78.3 percent / K2CO3 / dimethylformamide / 8 h / 110 °C
View Scheme
参考文献
Meunier, I.; Mishra, A. K.; Hanquet, B.; Cocolios, P.; Guilard, R.
Canadian Journal of Chemistry, 1995 , vol. 73, # 5 p. 685 - 695
反应条件
1.1: NH3 / methanol / 7 °C
2.1: BH3*THF / tetrahydrofuran / 7 h / Heating
3.1: conc. HCl
4.1: 58 percent / K2CO3 / tetrahydrofuran / 12 h
5.1: Cs2CO3 / acetonitrile / 0.5 h / Heating
5.2: 52 percent / acetonitrile / 72 h / Heating
View Scheme
参考文献
Rubio, Mercedes; Astorga, Covadonga; Alfonso, Ignacio; Rebolledo, Francisca; Gotor, Vicente
Synthetic Communications, 2002 , vol. 32, # 16 p. 2441 - 2452
反应条件
1.1: BH3*THF / tetrahydrofuran / 7 h / Heating
2.1: conc. HCl
3.1: 58 percent / K2CO3 / tetrahydrofuran / 12 h
4.1: Cs2CO3 / acetonitrile / 0.5 h / Heating
4.2: 52 percent / acetonitrile / 72 h / Heating
View Scheme
参考文献
Rubio, Mercedes; Astorga, Covadonga; Alfonso, Ignacio; Rebolledo, Francisca; Gotor, Vicente
Synthetic Communications, 2002 , vol. 32, # 16 p. 2441 - 2452
反应条件
1: 91 percent / sodium hydroxide / H2O / 1.) 1 hr., 5 deg C, 2.) r.t., 3 hrs.
2: 85 percent / tetrabutylammonium iodide, sodium hydroxide (50 percent) / toluene; H2O / 9 h / Heating
View Scheme
参考文献
Luk'yanenko, N.G.; Basok, S.S.; Filonova, L.K.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, p. 1562 - 1571
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 8 p. 1731 - 1742
反应条件
1: 35 percent / 96percent aq. H2SO4 / 50 h / 110 °C
2: 1.2 g / dimethylformamide / 2 h / 110 - 120 °C
View Scheme
参考文献
Meunier, I.; Mishra, A. K.; Hanquet, B.; Cocolios, P.; Guilard, R.
Canadian Journal of Chemistry, 1995 , vol. 73, # 5 p. 685 - 695
