1: methyl iodide With iodine; magnesium in diethyl ether Inert atmosphere; 2: 2-bromo-4,5-methylenedioxybenzaldehyde in diethyl ether T=-10°C; Grignard reaction; 3 h; Inert atmosphere; 3: With ammonium chloride in diethyl ether; water Inert atmosphere;

in tetrahydrofuran 1.) 0 deg C, 1.5 h 2.) room temp., 3 h;

N-bromosuccinmide in acetonitrile T=20°C; 0.5 h;

in diethyl ether T=0 - 20°C; 3 h; Inert atmosphere;

1: sodium tetrahydroborate / |Schlenk technique; |Inert atmosphere 2: |Schlenk technique; |Inert atmosphere View Scheme

Grignard Reaction; Schlenk techniqueInert atmosphere;

silica gel; pyridinium chlorochromate in dichloromethane T=20°C; 2 h; Inert atmosphere;