2-甲基-联苯-2-羧酸合成路线 （共 19 条）
反应条件
1: 4-dimethylaminopyridine, pyridine / benzene / 4 h / Ambient temperature
2: 70 percent / diethyl ether; benzene / 20 h / Ambient temperature
3: 97 percent / aq. KOH / ethanol / 0.5 h / Heating
View Scheme
参考文献
Hattori, Tetsutaro; Suzuki, Takatsugu; Hayashizaka, Noriyuki; Koike, Nobuyuki; Miyano, Sotaro
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 10 p. 3034 - 3040
反应条件
1: 1.) n-BuLi, 2.) ZnCl2, 3.) MeMgBr, Ni(PPh3)2Cl2
2: 96 percent / 1 N NaOH / ethanol / 18 h / Ambient temperature
View Scheme
参考文献
Matsuhisa, Akira; Tanaka, Akihiro; Kikuchi, Kazumi; Shimada, Yoshiaki; Yatsu, Takeyuki; Yanagisawa, Isao
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 11 p. 1870 - 1874
反应条件
1: 1.) n-BuLi, 2.) ZnCl2, 3.) MeMgBr, Ni(PPh3)2Cl2
2: 96 percent / 1 N NaOH / ethanol / 18 h / Ambient temperature
View Scheme
参考文献
Matsuhisa, Akira; Tanaka, Akihiro; Kikuchi, Kazumi; Shimada, Yoshiaki; Yatsu, Takeyuki; Yanagisawa, Isao
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 11 p. 1870 - 1874
反应条件
1: 70 percent / diethyl ether; benzene / 20 h / Ambient temperature
2: 97 percent / aq. KOH / ethanol / 0.5 h / Heating
View Scheme
参考文献
Hattori, Tetsutaro; Suzuki, Takatsugu; Hayashizaka, Noriyuki; Koike, Nobuyuki; Miyano, Sotaro
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 10 p. 3034 - 3040
反应条件
1: 85 percent / diethyl ether; benzene / 20 h / Ambient temperature
2: 97 percent / aq. KOH / ethanol / 1 h / Heating
View Scheme
参考文献
Hattori, Tetsutaro; Suzuki, Takatsugu; Hayashizaka, Noriyuki; Koike, Nobuyuki; Miyano, Sotaro
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 10 p. 3034 - 3040
反应条件
1: 96 percent / diethyl ether; benzene / 1.) RT, 20 h, 2.) reflux, 1 h
2: 95 percent / NaOCH3 / hexamethylphosphoric acid triamide; toluene / 1.5 h / Heating
View Scheme
参考文献
Hattori, Tetsutaro; Suzuki, Takatsugu; Hayashizaka, Noriyuki; Koike, Nobuyuki; Miyano, Sotaro
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 10 p. 3034 - 3040
反应条件
1: 1.) Mg / 1.) THF, 80 deg C, 0.5 h, 2.) THF, 40 deg C, 5 h
2: 50 percent / 6 N aq. HCl / 60 h / Heating
View Scheme
参考文献
Ohkawa, Takehiko; Zenkoh, Tatsuya; Tomita, Masayuki; Hosogai, Naomi; Hemmi, Keiji; Tanaka, Hirokazu; Setoi, Hiroyuki
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 4 p. 501 - 510
反应条件
hydrogenchloride; sodium hydroxide
Yield given. Multistep reaction;
参考文献
Dorra, Michael; Gomann, Klaus; Guth, Michael; Kirmse, Wolfgang
Journal of Physical Organic Chemistry, 1996 , vol. 9, # 9 p. 598 - 610
反应条件
(i) copper bronze, (heating), (ii) aq. KOH; Multistep reaction;
参考文献
Davies,D.I.; Waring,C.
Journal of the Chemical Society [Section] C: Organic, 1967 , p. 1639 - 1642
