6-(苄氧基)-1-己醇合成路线 （共 26 条）
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in dichloromethane; water
T=20°C;
参考文献
Reddy, Ch. Raji; Chittiboyina, Amar G.; Kache, Rajashaker; Jung, Jae-Chul; Watkins, E. Blake; Avery, Mitchell A.
Tetrahedron, 2005 , vol. 61, # 5 p. 1289 - 1295
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
6 h; Ambient temperature;
参考文献
Halcomb; Huang; Wong
Journal of the American Chemical Society, 1994 , vol. 116, # 25 p. 11315 - 11322
反应条件
1: 42.06 g / TfOH / CH2Cl2 / 18 h / 0 °C
2: LiAlH4 / tetrahydrofuran / 6 h / Ambient temperature
View Scheme
参考文献
Halcomb; Huang; Wong
Journal of the American Chemical Society, 1994 , vol. 116, # 25 p. 11315 - 11322
反应条件
1: 42.06 g / TfOH / CH2Cl2 / 18 h / 0 °C
2: LiAlH4 / tetrahydrofuran / 6 h / Ambient temperature
View Scheme
参考文献
Halcomb; Huang; Wong
Journal of the American Chemical Society, 1994 , vol. 116, # 25 p. 11315 - 11322
反应条件
methylmagnesium bromide in tetrahydrofuran
T=0°C; 20 h;
参考文献
Cossy; Ranaivosata; Bellosta; Wietzke
Synthetic Communications, 1995 , vol. 25, # 20 p. 3109 - 3112
反应条件
silver(l) oxide in dichloromethane
4 h; Ambient temperature;
参考文献
Bouzide, Abderrahim; Sauve, Gilles
Tetrahedron Letters, 1997 , vol. 38, # 34 p. 5945 - 5948
反应条件
sodium; xylene
T=120 - 130°C; anschliessendes Kochen mit 1.2 Mol Benzylchlorid;
参考文献
Wasserman; Dawson
Journal of Organic Chemistry, 1943 , vol. 8, p. 73,77
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 4 h;
参考文献
Yu, Wenquan; Gill, Tina; Wang, Lijuan; Du, Yanming; Ye, Hong; Qu, Xiaowang; Guo, Ju-Tao; Cuconati, Andrea; Zhao, Kang; Block, Timothy M.; Xu, Xiaodong; Chang, Jinhong
Journal of Medicinal Chemistry, 2012 , vol. 55, # 13 p. 6061 - 6075
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 160 °C / Inert atmosphere; Microwave irradiation
3: 5 Pd(II)/C(eggshell); hydrogen; palladium(II) oxide hydrate / tetrahydrofuran / 2 h / Inert atmosphere
View Scheme
参考文献
Van Oosten, Erik M.; Wilson, Alan A.; Mamo, David C.; Pollock, Bruce G.; Mulsant, Benoit H.; Houle, Sylvain; Vasdev, Neil
Canadian Journal of Chemistry, 2010 , vol. 88, # 12 p. 1222 - 1232
反应条件
1.1: tetrabutylammomium bromide; sodium acetate; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C / Molecular sieve
2.1: magnesium / diethyl ether / 2.5 h / 20 °C
2.2: 3 h / -78 - 0 °C
3.1: phosphorus tribromide / dichloromethane / 1 h / 0 °C
4.1: diMe-Imd-BH3; t-DDT; t-BuON=NOt-Bu / benzene / 2 h / 80 °C
View Scheme
参考文献
Pan, Xiangcheng; Lacote, Emmanuel; Lalevee, Jacques; Curran, Dennis P.
Journal of the American Chemical Society, 2012 , vol. 134, # 12 p. 5669 - 5674
