3-(苯基硒基)-L-丙氨酸合成路线 （共 5 条）
反应条件
phosphate buffer; Crotalus adamanteus L-amino acid oxidase; N-(carboxymethoxy)-amine T=37°C; pH=7.2; 0.333333 h; Enzyme kineticsProduct distribution; Further Variations:Reagents;
参考文献
Rooseboom; Vermeulen; Van Hemert; Commandeur
Chemical Research in Toxicology, 2001 , vol. 14, # 8 p. 996 - 1005
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 2 h;
参考文献
Phadnis, Prasad P.; Mugesh
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 13 p. 2476 - 2481
反应条件
1: aq. NaOH / methanol / 0.5 h / 0 - 5 °C
2: TFA / CH2Cl2 / 2 h / 20 °C
View Scheme
参考文献
Phadnis, Prasad P.; Mugesh
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 13 p. 2476 - 2481
反应条件
1: With diisopropyl-carbodiimide in N,N-dimethyl-formamide
1.5 h;
2: With piperidine in N,N-dimethyl-formamide
参考文献
Just-Baringo, Xavier; Bruno, Paolo; Ottesen, Lars K.; Canedo, Librada M.; Albericio, Fernando; Alvarez, Mercedes
Angewandte Chemie - International Edition, 2013 , vol. 52, # 30 p. 7818 - 7821
Angew. Chem., 2013 , vol. 52, # 30 p. 7818 - 7821,4
反应条件
sodium hydroxide; sodium tetrahydroborate
1.) EtOH, from 0 deg C to RT, 2.) EtOH, RT, 3 h; Yield given. Multistep reaction;
参考文献
Andreadou; Menge; Commandeur; Worthington; Vermeulen
Journal of Medicinal Chemistry, 1996 , vol. 39, # 10 p. 2040 - 2046
