2-苯基-1,3-噻唑-4-甲酸合成路线 (共 25 条)
反应条件
water; sodium hydroxide in methanol T=20°C; 1.03 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.
Patent: WO2013/163279 A1, 2013 ;
Location in patent: Paragraph 00217 ;
反应条件
sodium hydroxide; ethyl acetate in methanol T=0°C; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 7 p. 2584 - 2588
反应条件
in 1,4-dioxane 2 h; Heating / reflux;
参考文献
Gillespie, Paul; Goodnow, Robert Alan; Kowalczyk, Agnieszka; Le, Kang; Zhang, Qiang
Patent: US2007/167622 A1, 2007 ;
Location in patent: Page/Page column 13 ;
US 20070167622 A1
反应条件
1: ethanol / 90 °C 2: aq. NaOH / methanol / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 53, # 4 p. 437 - 440
反应条件
chromium(VI) oxide; sulfuric acid
参考文献
Journal of the American Chemical Society, , vol. 65, p. 1667,1669
参考文献
Journal of the American Chemical Society, , vol. 65, p. 2167
反应条件
1: With pyridine in tetrahydrofuran T=20°C; 2 h; 2: With water; trifluoroacetic acid in acetonitrile 0.333333 h; Further stages.;
参考文献
Journal of Organic Chemistry, , vol. 72, # 19 p. 7447 - 7450
反应条件
1: aqueous NaOH 2: CrO3; H2SO4 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 65, p. 1667,1669
反应条件
1: ethanolic KOH 2: 200 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 27, p. 1432,1433
反应条件
1: 48 percent / N-bromosuccinamide; benzoyl peroxide / CCl4 / 6 h / Heating 2: aq. NaOH; EtOAc / methanol / 2 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 7 p. 2584 - 2588