2-苯基-1,3-噻唑-4-甲酸合成路线 （共 25 条）
反应条件
1: 4.7 g / aq. NaHCO3 / ethanol / 3 h / CHCl3 2: 48 percent / N-bromosuccinamide; benzoyl peroxide / CCl4 / 6 h / Heating 3: aq. NaOH; EtOAc / methanol / 2 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 7 p. 2584 - 2588
反应条件
1: NaOH / methanol; H2O 2: (i) Et3N, ClCO2Et, THF, (ii) NaN3, H2O, (iii) /BRN= 385737/, AcOH 3: aq. HCl View Scheme
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 16, p. 1357 - 1360
反应条件
1: POCl3 / pyridine 2: NH3, H2S / methanol 3: ethanol 4: NaOH / methanol; H2O 5: (i) Et3N, ClCO2Et, THF, (ii) NaN3, H2O, (iii) /BRN= 385737/, AcOH 6: aq. HCl View Scheme
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 16, p. 1357 - 1360
反应条件
1: NH3, H2S / methanol 2: ethanol 3: NaOH / methanol; H2O 4: (i) Et3N, ClCO2Et, THF, (ii) NaN3, H2O, (iii) /BRN= 385737/, AcOH 5: aq. HCl View Scheme
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 16, p. 1357 - 1360
反应条件
1: ethanol 2: NaOH / methanol; H2O 3: (i) Et3N, ClCO2Et, THF, (ii) NaN3, H2O, (iii) /BRN= 385737/, AcOH 4: aq. HCl View Scheme
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 16, p. 1357 - 1360
反应条件
1: diethyl ether; ethanol 2: NaOBr View Scheme
参考文献
Bulletin de la Societe Chimique de France, , p. 3862 - 3866
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 16, p. 1357 - 1360
参考文献
Bulletin de la Societe Chimique de France, , p. 3862 - 3866
反应条件
1: (i) Et3N, ClCO2Et, THF, (ii) NaN3, H2O, (iii) /BRN= 385737/, AcOH 2: aq. HCl View Scheme
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 16, p. 1357 - 1360
反应条件
(i) NaNO2, aq. HCl, AcOH, H2O, (ii) Ac2O, (iii) aq. HCl; Multistep reaction;
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 16, p. 1357 - 1360
