2-苯基-1,3-噻唑-4-甲酸合成路线 （共 25 条）
参考文献
Larsen, Scott D.; Stachew, Carl F.; Clare, Paula M.; Cubbage, Jerry W.; Leach, Karen L.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3491 - 3495
反应条件
1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 4 h / 22 °C 2: triethylamine / dichloromethane / 1 h / 20 °C / |Cooling with ice 3: tetrahydrofuran; anhydrous butyl ether / 0.53 h / 0 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.
Patent: WO2013/163279 A1, 2013 ;
反应条件
1.1: 92 percent / 1-hydroxybenzotriazole; EDC / dimethylformamide / 3 h / 20 °C
2.1: 73 percent / sodium periodate / H2O; tetrahydrofuran / 3 h / 20 °C
3.1: trifluoroacetic anhydride; pyridine / tetrahydrofuran
3.2: tetrahydrofuran
View Scheme
参考文献
Xu, Libo; Farthing, Amy K.; Shi, Yao-Jun; Meinke, Peter T.; Liu, Kun
Journal of Organic Chemistry, 2007 , vol. 72, # 19 p. 7447 - 7450
反应条件
in methanol; diethyl ether
参考文献
Hall; Walker
Journal of the Chemical Society. Perkin transactions 1, 1966 , vol. 16, p. 1357 - 1360
反应条件
1: oxalyl chloride; DMF / CH2Cl2 / 20 °C
2: NaN3 / tetrahydrofuran / 40 °C
View Scheme
参考文献
Larsen, Scott D.; Stachew, Carl F.; Clare, Paula M.; Cubbage, Jerry W.; Leach, Karen L.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3491 - 3495
