2-(溴甲基)苯甲酸乙酯合成路线 （共 38 条）
反应条件
2: P2O5 / ethanol 3: 2.) conc. HCl, 3.) HCl-gas / 1.) THF, toluene, 65 deg C, 2 h, 2.) 1 h, 3.) 75 deg C, 1.5 h, ethanol View Scheme
参考文献
Jalander, Lars; Oksanen, Lasse; Taehtinen, Johanna
Synthetic Communications, 1989 , vol. 19, # 19 p. 3349 - 3352
反应条件
1: Et3N / diethyl ether / Heating 2: sodium ethoxide / benzene / 6 h / Heating 3: 72 percent / ethanol / 24 h / Heating 4: 62 percent / LiI*3H2O / dimethylformamide / 72 h / Heating View Scheme
参考文献
Allen; Skolnick; Cook
Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 368 - 374
反应条件
1: 43 percent / Zn / 4 h / 80 - 90 °C 2: 92 percent / KOH / methanol; H2O / 20 h / Heating 3: SOCl2 / 17 h / Heating 4: 57 percent / AlCl3 / 2 h / Ambient temperature 5: 50 percent / hydrazine hydrate / ethanol / 96 h / Heating View Scheme
参考文献
Hannemann, Klaus; Wirz, Jakob; Riesen, Andreas
Helvetica Chimica Acta, 1988 , vol. 71, p. 1841 - 1857
反应条件
1: 95 percent / ethanol / 5 h / Heating
2: 80 percent / 1percent NaOH / benzene; H2O / 1 h / Ambient temperature
View Scheme
参考文献
Kagabu, Shinzo; Kaku, Itone
Bioscience, Biotechnology, and Biochemistry, 1993 , vol. 57, # 11 p. 1899 - 1901
反应条件
bis(cyclopentadienyl)titanium dichloride; zinc in tetrahydrofuran
T=20°C; radical induced Barbier-type reaction;
参考文献
Mandal, Samir Kumar; Roy, Subhas Chandra
Tetrahedron, 2008 , vol. 64, # 49 p. 11050 - 11057
反应条件
bis(cyclopentadienyl)titanium dichloride; zinc in tetrahydrofuran
T=20°C; radical induced Barbier-type reaction;
参考文献
Mandal, Samir Kumar; Roy, Subhas Chandra
Tetrahedron, 2008 , vol. 64, # 49 p. 11050 - 11057
反应条件
1: 90 percent / potassium carbonate / acetone / 20 °C
2: 88 percent / sodium borohydride / methanol / 1 h
View Scheme
参考文献
Prasad, Chalasani S.N.; Varala, Ravi; Adapa, Srinivas R.
Heterocyclic Communications, 2002 , vol. 8, # 3 p. 281 - 286
反应条件
1: With titanocene(III) chloride in tetrahydrofuran
T=20°C; 13 h;
2: With sulfuric acid; water in tetrahydrofuran
参考文献
Mandal, Samir Kumar; Roy, Subhas Chandra
Tetrahedron, 2008 , vol. 64, # 49 p. 11050 - 11057
反应条件
methanol
Erwaermen des Reaktionsprodukts mit wss.-aethanol. Natronlauge;
参考文献
Clemo; Swan
Journal of the Chemical Society, 1946 , p. 617,621
Journal of the Chemical Society, 1949 , p. 487,491
反应条件
1: 79 percent / ethanol; H2O / 4 h / Heating
2: 94 percent / aq. NaOH / 5 h / 40 °C
3: 90 percent / PCl5 / diethyl ether / 7 h / 0 - 2 °C
View Scheme
参考文献
Canepa, Alicia S.; Bravo, Rodolfo D.
Synthetic Communications, 2004 , vol. 34, # 4 p. 579 - 588
