3-(4-硝基苯基)-丙酸乙酯合成路线 （共 13 条）
反应条件
N,N-dicyclohexylmethylamine; tetrabutylammomium bromide; 4-hydroxyacetophenone oxime-derived palladacycle catalyst in N,N-dimethyl acetamide; water
T=120°C; Heck coupling; 3 h;
参考文献
Najera, Carmen; Botella, Luis
Tetrahedron, 2005 , vol. 61, # 41 p. 9688 - 9695
反应条件
tributyl-amine; tetrabutyl-ammonium chloride; palladium diacetate in N,N-dimethyl-formamide
T=90°C; 1 h;
参考文献
Battistuzzi, Gianfranco; Cacchi, Sandro; Fabrizi, Giancarlo; Bernini, Roberta
Synlett, 2003 , # 8 p. 1133 - 1136
反应条件
1: With N,N-dicyclohexylmethylamine; tetrabutylammomium bromide in N,N-dimethyl-formamide
T=120°C; Heck reaction; 6 h;
2: With hydrogenchloride in water; ethyl acetate
T=20°C; chemoselective reaction;
参考文献
Alacid, Emilio; Najera, Carmen
European Journal of Organic Chemistry, 2008 , # 18 p. 3102 - 3106
反应条件
bis (triortho-tolylphosphine)palladium(II) chloride in N,N-dimethyl acetamide; benzene
T=60°C; 1 h;
参考文献
Tamaru, Y.; Ochiai, H.; Nakamura, T.; Yoshida, Z.
Tetrahedron Letters, 1986 , vol. 27, # 8 p. 955 - 958
反应条件
tetrakis(dimethylamino)ethylene in N,N-dimethyl-formamide
T=-20 - 70°C; 3 h; Inert atmosphere;
参考文献
Since, Marc; Terme, Thierry; Vanelle, Patrice
Tetrahedron, 2009 , vol. 65, # 31 p. 6128 - 6134
反应条件
C50H57IrN2P; hydrogen in dichloromethane
T=-78 - 20°C;
参考文献
Bennie, Linsey S.; Fraser, Calum J.; Irvine, Stephanie; Kerr, William J.; Andersson, Shalini; Nilsson, Goeran N.
Chemical Communications, 2011 , vol. 47, # 42 p. 11653 - 11655
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Bohman; Nordlander; Nordenhem; Sunnerheim; Borg-Karlson; Unelius
Journal of Chemical Ecology, 2008 , vol. 34, # 3 p. 339 - 352
反应条件
hydrogenchloride; N,N-dicyclohexylmethylamine; tetrabutylammomium bromide in N,N-dimethyl acetamide; water
T=20°C; 0.166667 h; chemoselective reaction;
参考文献
Susanto, Woen; Chu, Chi-Yuan; Ang, Wei Jie; Chou, Tzyy-Chao; Lo, Lee-Chiang; Lam, Yulin
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2729 - 2742
反应条件
1: sodium hydride / tetrahydrofuran
2: sodium chloride / dimethyl sulfoxide
View Scheme
参考文献
Jayasekara, P. Suresh; Barrett, Matthew O.; Ball, Christopher B.; Brown, Kyle A.; Hammes, Eva; Balasubramanian, Ramachandran; Harden, T. Kendall; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 9 p. 3874 - 3883
反应条件
Pd2(μ-C6H4PPh2)2(μ-C9H7NPPh2)(μ-O2CCH3); water; caesium carbonate in tetrahydrofuran; methanol
Suzuki coupling; 24 h; RefluxInert atmosphere;
参考文献
Bonet, Amadeu; Gulyas, Henrik; Koshevoy, Igor O.; Estevan, Francisco; Sanau, Mercedes; Ubeda, M. Angeles; Fernandez, Elena
Chemistry - A European Journal, 2010 , vol. 16, # 21 p. 6382 - 6390
