反应条件
1: 43 percent / t-BuOOH, Ti(O-i-Pr)4, D-(-)-DIPT, molecular sieves 4 Angstroem / CH2Cl2 / 21 h / -21 °C 2: Br2 / CH2Cl2 / 0.17 h / -70 °C 3: n-Bu4NF / tetrahydrofuran / 0.25 h / -70 °C 4: imidazole / dimethylformamide / 5 h / Ambient temperature 5: n-PrNH2 / Pd(PPh3)4, CuI / benzene / 20 h / Ambient temperature 6: 1) AgNO3, 2) KCN / 1) THF, EtOH, H2O, 0 deg C, 30 min, 2) 0 deg C, 30 min 7: 1) disiamylborane, 2) LiOH / 2) Pd(PPh3)4 / 1) THF, 0 deg C, 1h, 2) 40 deg C, 18h 8: 85 percent / n-Bu4NF / tetrahydrofuran / 17 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 19 p. 5324 - 5335
