2,2-二氧-1-甲基-2,1-苯并噻唑酮合成路线 （共 10 条）
反应条件
sodium hydride in N,N-dimethyl-formamide
T=20°C; 1.5 h;
参考文献
Shafiq, Muhammad; Zia-Ur-Rehman, Muhammad; Khan, Islam Ullah; Arshad, Muhammad Nadeem; Khan, Siraj Ahmed
Journal of the Chilean Chemical Society, 2011 , vol. 56, # 1 p. 527 - 531
反应条件
sodium hydride in N,N-dimethyl-formamide
T=20°C; 4 h;
参考文献
Volovenko, Yulian; Volovnenko, Tatyana; Popov, Kirill
Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 6 p. 1413 - 1419
反应条件
(i) NaH, DMF, (ii) aq. HCl; Multistep reaction;
参考文献
Lombardino,J.G. et al.
Journal of Heterocyclic Chemistry, 1972 , vol. 9, p. 315 - 317
反应条件
sulfuric acid
Ambient temperature;
参考文献
Cecchetti; Fravolini; Schiaffella
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 5 p. 1045 - 1050
反应条件
1.1: dichloromethane / 0.5 h / 40 °C / Ultrasonic irradiation
2.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h
2.2: 1.42 h / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 20 °C
View Scheme
参考文献
Shafiq, Muhammad; Zia-Ur-Rehman, Muhammad; Khan, Islam Ullah; Arshad, Muhammad Nadeem; Khan, Siraj Ahmed
Journal of the Chilean Chemical Society, 2011 , vol. 56, # 1 p. 527 - 531
反应条件
1: triethylamine / dichloromethane / 5 h / -5 - 0 °C
2: potassium hydroxide; water / 240 h / 20 °C
View Scheme
参考文献
Ukrainets; Petrushova; Dzyubenko
Chemistry of Heterocyclic Compounds, 2013 , vol. 49, # 9 p. 1378 - 1383
Khim. Geterotsikl. Soedin., 2013 , vol. 49, # 9 p. 1479 - 1485,7
参考文献
Cecchetti; Fravolini; Schiaffella
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 5 p. 1045 - 1050
参考文献
Cecchetti; Fravolini; Schiaffella
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 5 p. 1045 - 1050
反应条件
1: 56.7 percent / polyphosphoric acid / 2 h / 80 °C
2: 1) BF3*Et2O, 2) NH2OH*HCl / 1) reflux, 1 h, 2) acetic acid, 180 deg C, 45 min
View Scheme
参考文献
Cecchetti; Fravolini; Schiaffella
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 5 p. 1045 - 1050
反应条件
1: 56.7 percent / polyphosphoric acid / 2 h / 80 °C
2: 67.3 percent / toluene / 1 h / Heating
3: 70.2 percent / NH2OH*HCl / acetic acid / 0.25 h / 180 °C
View Scheme
参考文献
Cecchetti; Fravolini; Schiaffella
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 5 p. 1045 - 1050
