3-溴丙烷-1,1,1-三羧酸三乙酯合成路线 （共 5 条）
反应条件
1: triethyl methanetricarboxylate With sodium ethanolate in diethyl ether T=0 - 20°C; Metallation; 0.5 h; 2: ethylene dibromide in N,N-dimethyl-formamide T=90°C; Condensation; 10 h; Further stages.;
参考文献
Kim, Yong-Chul; Gallo-Rodriguez, Carola; Jang, Soo-Yeon; Nandanan, Erathodiyil; Adams, Mary; Harden, T. Kendall; Boyer, Jose L.; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 4 p. 746 - 755
反应条件
1: Na / ethanol; diethyl ether 2: benzene; dimethylformamide View Scheme
参考文献
Journal of Organic Chemistry, , vol. 44, # 20 p. 3492 - 3496
反应条件
in N,N-dimethyl-formamide; benzene
参考文献
Journal of Organic Chemistry, , vol. 44, # 20 p. 3492 - 3496
反应条件
potassium carbonate 1.) DMF, 60 deg C, 22 h, 2.) MeOH, 15-20 deg C, 1.5 h; Yield given. Multistep reaction;
参考文献
Choudary, Bernadette M.; Geen, Graham R.; Kincey, Peter M.; Parratt, Martin J.; Dales, J. Robert M.; Johnson, Graham P.; O'Donnell, Steven; Tudor, David W.; Woods, Neil
Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 981 - 994
反应条件
1: 61 percent / K2CO3 / dimethylformamide / 16 h / 40 °C
2: 98 percent / HCO2NH4 / Pd-C / methanol / 2 h / Heating
3: 78 percent / Na, EtOH / 1 h / Ambient temperature
View Scheme
参考文献
Choudary, Bernadette M.; Geen, Graham R.; Kincey, Peter M.; Parratt, Martin J.; Dales, J. Robert M.; Johnson, Graham P.; O'Donnell, Steven; Tudor, David W.; Woods, Neil
Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 981 - 994
