2-(4-氟苯基)-4,4-二甲基-2-噁唑啉合成路线 （共 8 条）
反应条件
thionyl chloride
T=20°C; 0.25 h;
参考文献
ASTRAZENECA AB
Patent: US2008/15237 A1, 2008 ;
Location in patent: Page/Page column 33 ;
US 20080015237 A1
反应条件
C2H3O2(1-)*C20H30OP(1-)*C20H31OP*Pd(2+); lithium tert-butylate in N,N-dimethyl acetamide
T=100°C; 14 h; Inert atmosphere;
参考文献
Ackermann, Lutz; Barfuesser, Sebastian; Kornhaass, Christoph; Kapdi, Anant R.
Organic Letters, 2011 , vol. 13, # 12 p. 3082 - 3085
反应条件
hydrogenchloride; thionyl chloride in potassium hydroxide; diethyl ether; dichloromethane
参考文献
Pfizer Inc.
Patent: US6051601 A1, 2000 ;
US 6051601 A
反应条件
1: BuLi / diethyl ether / -78 °C
2: 1) trimethyltin chloride (Me3SnCl) / 2) (Ph3P)4Pd <tetrakis(triphenylphosphine)palladium(O)> / 1) in Et2O, -78 deg C, 2) C6H6, 24h, reflux
View Scheme
参考文献
Dondoni, Alessandro; Fogagnolo, Marco; Fantin, Giancarlo; Medici, Alessandro; Pedrini, Paola
Tetrahedron Letters, 1986 , vol. 27, # 43 p. 5269 - 5270
反应条件
trimethylstannyl chloride; tetrakis(triphenylphosphine) palladium(0)
1) in Et2O, -78 deg C, 2) C6H6, 24h, reflux; Yield given. Multistep reaction;
参考文献
Dondoni, Alessandro; Fogagnolo, Marco; Fantin, Giancarlo; Medici, Alessandro; Pedrini, Paola
Tetrahedron Letters, 1986 , vol. 27, # 43 p. 5269 - 5270
反应条件
2: SOCl2
View Scheme
参考文献
Newman,M.S.; Kannan,R.
Journal of Organic Chemistry, 1979 , vol. 44, p. 3388 - 3390
参考文献
Schull, Terence L.; Brandow, Susan L.; Dressick, Walter J.
Tetrahedron Letters, 2001 , vol. 42, # 32 p. 5373 - 5376
反应条件
thionyl chloride
Multistep reaction;
参考文献
Yamaguchi; Koga; Kamei; Akima; Maruyama; Kuroki; Hamana; Ohi
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 9 p. 1850 - 1853
