5-氨基-1,3-二羟基甲基苯合成路线 （共 12 条）
参考文献
Li Li; Dietrich; Hansch
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 535 - 544
反应条件
hydrogenchloride; sodium nitrite 1.) -5 deg C, 30 min, 2.) H2O, 0 deg C, 2 h; Yield givenMultistep reaction;
参考文献
Behrens, Carsten; Dahl, Otto
Nucleosides and Nucleotides, 1999 , vol. 18, # 2 p. 291 - 305
反应条件
hydrogen; nickel in sodium hydroxide T=20°C;
参考文献
Synthesis, , # 12 p. 1235 - 1236
反应条件
1: 85 percent / Et3N / tetrahydrofuran / 3 h / 20 °C 2: 89 percent / SOCl2; pyridine / CH2Cl2 / 18 h / 20 °C View Scheme
参考文献
Zheng, Jie; Lin, Shengyue; Jiang, Bi-Wang; Marder, Todd B.; Yang, Zhen
Canadian Journal of Chemistry, 2012 , vol. 90, # 1 p. 138 - 144
反应条件
hydrogen; palladium 10 on activated carbon in methanol
T=20°C; P=258.581 Torr; 2 h;
参考文献
IMMUNOGEN, INC.; LI, Wei; FISHKIN, Nathan, Elliott; ZHAO, Robert, Yongxin; MILLER, Michael, Louis; CHARI, Ravi, V., J.
Patent: WO2010/91150 A1, 2010 ;
Location in patent: Page/Page column 119-120 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
Reduction; 8 h; Heating;
参考文献
Bergbreiter, David E.; Osburn, Philip L.; Liu, Yun-Shan
Journal of the American Chemical Society, 1999 , vol. 121, # 41 p. 9531 - 9538
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
14 h; Heating;
参考文献
Yu, Kunquan; Sommer, William; Richardson, John M.; Weck, Marcus; Jones, Christopher W.
Advanced Synthesis and Catalysis, 2005 , vol. 347, # 1 p. 161 - 171
反应条件
1: 85 percent / H2SO4 / 16 h / Heating
2: 91 percent / LAH / tetrahydrofuran / 8 h / Heating
View Scheme
参考文献
Bergbreiter, David E.; Osburn, Philip L.; Liu, Yun-Shan
Journal of the American Chemical Society, 1999 , vol. 121, # 41 p. 9531 - 9538
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Li Li; Dietrich; Hansch
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 535 - 544
反应条件
1: 95 percent / H2 / Pd/C / methanol / 1 h / 20 °C / 760 Torr
2: 82 percent / conc. H2SO4 / 16 h / Heating
3: 82 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Behrens, Carsten; Dahl, Otto
Nucleosides and Nucleotides, 1999 , vol. 18, # 2 p. 291 - 305
