1: 81 percent / pyridine, piperidine / 1.) 80 deg C, 1 h, 2.) reflux, 1 h 2: 94 percent / DMAP, DCC / CH2Cl2 / 12 h / -20 - 20 °C 3: 92 percent / Pd(PPh3)4, morpholine / tetrahydrofuran / Ambient temperature View Scheme

potassium carbonate in N,N-dimethyl-formamide T=20°C; 1 h;

sodium hydride in dimethyl sulfoxide T=25°C; 17 h; NaH : pyrocatechlol 2.2; Yields of byproduct given;

sodium hydride in dimethyl sulfoxide T=25°C; 17 h; NaH : pyrocatechlol 1.1; Yields of byproduct given;

potassium carbonate; sodium iodide in methanol T=60°C; 16 h;